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• W2080641729 abstract "<i>Background:</i> Neuropathic pain is one of the most challenging clinical problems due to a lack of understanding the mechanisms. Recent studies have suggested that activated microglia in spinal cord may play a vital role in nerve injury-induced neuropathic pain, but the exact mechanisms have not been fully determined. <i>Methods:</i> First, we investigated the changes of dorsal horn GABA(B) receptor 1 (R1) expression in spinal nerve ligation rats. Second, we explored whether activated microglia contributed to such neuron changes by intrathecal administration of the p38 inhibitor, SB203580. <i>Results:</i> In this study, we found a dynamic change of GABA(B)R1a protein expression after spinal nerve ligation, and the peripheral nerve injury-induced downregulation of GABA(B)R1a expression in the spinal dorsal horn could be prevented by intrathecal administration of a p38/MAPK inhibitor SB203580. <i>Conclusions:</i> Our results provide valuable information for a better understanding of neuropathic pain and may contribute to developing effective treatments in future studies." @default.
• W2080641729 created "2016-06-24" @default.
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• W2080641729 date "2011-01-01" @default.
• W2080641729 modified "2023-09-26" @default.
• W2080641729 title "p38/MAPK Inhibitor Modulates the Expression of Dorsal Horn GABA(B) Receptors in the Spinal Nerve Ligation Model of Neuropathic Pain" @default.
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• W2080641729 doi "https://doi.org/10.1159/000323141" @default.
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