FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080642750> ?p ?o ?g. }

• W2080642750 endingPage "1217" @default.
• W2080642750 startingPage "1209" @default.
• W2080642750 abstract "Doxycycline hyclate (DOX) is a highly photosensitive drug, a feature that limits the stability of the corresponding dosage forms. The main objectives of this work were the preparation and characterization of an inclusion complex of DOX with β-cyclodextrin (βCD) and to investigate if this approach could improve the photostability of the drug. Guest-host interactions were investigated using nuclear magnetic resonance, which were afterwards combined with molecular modeling methods to study the complex formation and its three-dimensional structure was proposed. A freeze-drying method was applied to obtain the complex in the solid state, which was further confirmed by thermal and spectroscopic techniques. To evaluate the complexation effect on DOX integrity, the photostability of the inclusion complex was studied, with a significant decrease in the photodegradation of DOX being found in aqueous solution upon complexation. Finally, the photoprotection produced by the complexation was evaluated by means of an antimicrobial assay. Overall, the presented results suggest that the formulation of DOX complexed with βCD constitutes an interesting approach for the preparation of pharmaceutical dosage forms of DOX with enhanced stability properties." @default.
• W2080642750 created "2016-06-24" @default.
• W2080642750 creator A5008080549 @default.
• W2080642750 creator A5021816868 @default.
• W2080642750 creator A5029941486 @default.
• W2080642750 creator A5071150930 @default.
• W2080642750 creator A5088618670 @default.
• W2080642750 date "2014-06-03" @default.
• W2080642750 modified "2023-10-07" @default.
• W2080642750 title "Increasing Doxycycline Hyclate Photostability by Complexation with β-Cyclodextrin" @default.
• W2080642750 cites W1697337825 @default.
• W2080642750 cites W1980483501 @default.
• W2080642750 cites W1983469550 @default.
• W2080642750 cites W2009319589 @default.
• W2080642750 cites W2029667189 @default.
• W2080642750 cites W2029908607 @default.
• W2080642750 cites W2031676331 @default.
• W2080642750 cites W2036497646 @default.
• W2080642750 cites W2045649301 @default.
• W2080642750 cites W2046229956 @default.
• W2080642750 cites W2048214699 @default.
• W2080642750 cites W2048253785 @default.
• W2080642750 cites W2049293232 @default.
• W2080642750 cites W2061583504 @default.
• W2080642750 cites W2070626634 @default.
• W2080642750 cites W2074582913 @default.
• W2080642750 cites W2078374001 @default.
• W2080642750 cites W2079344989 @default.
• W2080642750 cites W2079684153 @default.
• W2080642750 cites W2088168780 @default.
• W2080642750 cites W2088323113 @default.
• W2080642750 cites W2098943363 @default.
• W2080642750 cites W2107001533 @default.
• W2080642750 cites W2107752894 @default.
• W2080642750 cites W2118233996 @default.
• W2080642750 cites W2126626785 @default.
• W2080642750 cites W2144569337 @default.
• W2080642750 cites W2147993766 @default.
• W2080642750 doi "https://doi.org/10.1208/s12249-014-0150-7" @default.
• W2080642750 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4179669" @default.
• W2080642750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24889734" @default.
• W2080642750 hasPublicationYear "2014" @default.
• W2080642750 type Work @default.
• W2080642750 sameAs 2080642750 @default.
• W2080642750 citedByCount "35" @default.
• W2080642750 countsByYear W20806427502015 @default.
• W2080642750 countsByYear W20806427502016 @default.
• W2080642750 countsByYear W20806427502017 @default.
• W2080642750 countsByYear W20806427502018 @default.
• W2080642750 countsByYear W20806427502019 @default.
• W2080642750 countsByYear W20806427502020 @default.
• W2080642750 countsByYear W20806427502021 @default.
• W2080642750 countsByYear W20806427502022 @default.
• W2080642750 countsByYear W20806427502023 @default.
• W2080642750 crossrefType "journal-article" @default.
• W2080642750 hasAuthorship W2080642750A5008080549 @default.
• W2080642750 hasAuthorship W2080642750A5021816868 @default.
• W2080642750 hasAuthorship W2080642750A5029941486 @default.
• W2080642750 hasAuthorship W2080642750A5071150930 @default.
• W2080642750 hasAuthorship W2080642750A5088618670 @default.
• W2080642750 hasBestOaLocation W20806427502 @default.
• W2080642750 hasConcept C13965031 @default.
• W2080642750 hasConcept C155574463 @default.
• W2080642750 hasConcept C161790260 @default.
• W2080642750 hasConcept C162847780 @default.
• W2080642750 hasConcept C178790620 @default.
• W2080642750 hasConcept C183688256 @default.
• W2080642750 hasConcept C184651966 @default.
• W2080642750 hasConcept C185592680 @default.
• W2080642750 hasConcept C21951064 @default.
• W2080642750 hasConcept C2779433975 @default.
• W2080642750 hasConcept C2780035454 @default.
• W2080642750 hasConcept C2780542282 @default.
• W2080642750 hasConcept C43617362 @default.
• W2080642750 hasConcept C55493867 @default.
• W2080642750 hasConcept C65165184 @default.
• W2080642750 hasConcept C71924100 @default.
• W2080642750 hasConcept C77281830 @default.
• W2080642750 hasConcept C98274493 @default.
• W2080642750 hasConceptScore W2080642750C13965031 @default.
• W2080642750 hasConceptScore W2080642750C155574463 @default.
• W2080642750 hasConceptScore W2080642750C161790260 @default.
• W2080642750 hasConceptScore W2080642750C162847780 @default.
• W2080642750 hasConceptScore W2080642750C178790620 @default.
• W2080642750 hasConceptScore W2080642750C183688256 @default.
• W2080642750 hasConceptScore W2080642750C184651966 @default.
• W2080642750 hasConceptScore W2080642750C185592680 @default.
• W2080642750 hasConceptScore W2080642750C21951064 @default.
• W2080642750 hasConceptScore W2080642750C2779433975 @default.
• W2080642750 hasConceptScore W2080642750C2780035454 @default.
• W2080642750 hasConceptScore W2080642750C2780542282 @default.
• W2080642750 hasConceptScore W2080642750C43617362 @default.
• W2080642750 hasConceptScore W2080642750C55493867 @default.
• W2080642750 hasConceptScore W2080642750C65165184 @default.
• W2080642750 hasConceptScore W2080642750C71924100 @default.
• W2080642750 hasConceptScore W2080642750C77281830 @default.
• W2080642750 hasConceptScore W2080642750C98274493 @default.
• W2080642750 hasIssue "5" @default.

• next