FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080644501> ?p ?o ?g. }

• W2080644501 endingPage "528" @default.
• W2080644501 startingPage "518" @default.
• W2080644501 abstract "The expression of proenkephalin (PENK) mRNA in C6 rat glioma cells was stimulated by norepinephrine (a β-adrenergic agonist) and markedly enhanced by the addition of dexamethasone (a glucocorticoid agonist) to the culture medium, although dexamethasone alone exhibited no significant increase in PENK mRNA. Furthermore, no induction of glucocorticoid-response-element (GRE)-binding proteins was detectable. In contrast, the stimulation of PENK mRNA expression was not observed with a protein kinase C activator, 12-tetradecanoylphorbol-13-acetate (TPA), which stimulated the expression of c-fos and c-jun mRNA and their proto-oncoproteins (c-Fos and c-Jun). In addition, an AP-1 activity was induced by TPA and an induction of a κB-like binding activity was found with TPA plus cycloheximide-treated cells. Together, they suggest that activation of PENK gene in C6 cells is probably mediated mainly through the, β-adrenergic agonist-elicited cyclic AMP signal pathway, and induction of AP-1 and κB-like binding activities appear not to participate in gene activation. Interestingly, the Western blot data showed no increase in intracellular levels of proenkephalin between control and treated cells. However, a marked increase in immunoreactivities for proenkephalin and its derivative, [Met5]-enkephalin was detected in medium and a lesser elevation in cells from modulator-treated cell culture through the time course. These results indicated that there was an association between an increase in PENK mRNA expression and an elevation of proenkephalins, and subsequently, the synthesized proenkephalins were released into the medium." @default.
• W2080644501 created "2016-06-24" @default.
• W2080644501 creator A5056696922 @default.
• W2080644501 creator A5058415147 @default.
• W2080644501 creator A5062673078 @default.
• W2080644501 date "1992-12-01" @default.
• W2080644501 modified "2023-09-24" @default.
• W2080644501 title "Regulation of proenkephalin expression in C6 rat glioma cells" @default.
• W2080644501 cites W112561125 @default.
• W2080644501 cites W1529166175 @default.
• W2080644501 cites W1545582911 @default.
• W2080644501 cites W1559810631 @default.
• W2080644501 cites W1573850071 @default.
• W2080644501 cites W1577760777 @default.
• W2080644501 cites W1869254767 @default.
• W2080644501 cites W1869906673 @default.
• W2080644501 cites W1943482784 @default.
• W2080644501 cites W1965267927 @default.
• W2080644501 cites W1967346650 @default.
• W2080644501 cites W1967650818 @default.
• W2080644501 cites W1975286857 @default.
• W2080644501 cites W1993243592 @default.
• W2080644501 cites W1994711432 @default.
• W2080644501 cites W2000371106 @default.
• W2080644501 cites W2004563262 @default.
• W2080644501 cites W2010051841 @default.
• W2080644501 cites W2017670145 @default.
• W2080644501 cites W2025314368 @default.
• W2080644501 cites W2028158224 @default.
• W2080644501 cites W2053051844 @default.
• W2080644501 cites W2053995748 @default.
• W2080644501 cites W2059559415 @default.
• W2080644501 cites W2066232621 @default.
• W2080644501 cites W2067388503 @default.
• W2080644501 cites W2068849212 @default.
• W2080644501 cites W2075779383 @default.
• W2080644501 cites W2076808452 @default.
• W2080644501 cites W2079002609 @default.
• W2080644501 cites W2080288217 @default.
• W2080644501 cites W2081135713 @default.
• W2080644501 cites W2081304551 @default.
• W2080644501 cites W2088065967 @default.
• W2080644501 cites W2092602709 @default.
• W2080644501 cites W2093710529 @default.
• W2080644501 cites W2094817094 @default.
• W2080644501 cites W2100837269 @default.
• W2080644501 cites W2416022039 @default.
• W2080644501 doi "https://doi.org/10.1016/1044-7431(92)90064-9" @default.
• W2080644501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19912895" @default.
• W2080644501 hasPublicationYear "1992" @default.
• W2080644501 type Work @default.
• W2080644501 sameAs 2080644501 @default.
• W2080644501 citedByCount "8" @default.
• W2080644501 countsByYear W20806445012023 @default.
• W2080644501 crossrefType "journal-article" @default.
• W2080644501 hasAuthorship W2080644501A5056696922 @default.
• W2080644501 hasAuthorship W2080644501A5058415147 @default.
• W2080644501 hasAuthorship W2080644501A5062673078 @default.
• W2080644501 hasConcept C104317684 @default.
• W2080644501 hasConcept C105580179 @default.
• W2080644501 hasConcept C126322002 @default.
• W2080644501 hasConcept C134018914 @default.
• W2080644501 hasConcept C150194340 @default.
• W2080644501 hasConcept C153911025 @default.
• W2080644501 hasConcept C170493617 @default.
• W2080644501 hasConcept C177707886 @default.
• W2080644501 hasConcept C2777515746 @default.
• W2080644501 hasConcept C2777803847 @default.
• W2080644501 hasConcept C2778128677 @default.
• W2080644501 hasConcept C2778938600 @default.
• W2080644501 hasConcept C2780841215 @default.
• W2080644501 hasConcept C2781063702 @default.
• W2080644501 hasConcept C2781085546 @default.
• W2080644501 hasConcept C3675279 @default.
• W2080644501 hasConcept C55493867 @default.
• W2080644501 hasConcept C71924100 @default.
• W2080644501 hasConcept C86803240 @default.
• W2080644501 hasConceptScore W2080644501C104317684 @default.
• W2080644501 hasConceptScore W2080644501C105580179 @default.
• W2080644501 hasConceptScore W2080644501C126322002 @default.
• W2080644501 hasConceptScore W2080644501C134018914 @default.
• W2080644501 hasConceptScore W2080644501C150194340 @default.
• W2080644501 hasConceptScore W2080644501C153911025 @default.
• W2080644501 hasConceptScore W2080644501C170493617 @default.
• W2080644501 hasConceptScore W2080644501C177707886 @default.
• W2080644501 hasConceptScore W2080644501C2777515746 @default.
• W2080644501 hasConceptScore W2080644501C2777803847 @default.
• W2080644501 hasConceptScore W2080644501C2778128677 @default.
• W2080644501 hasConceptScore W2080644501C2778938600 @default.
• W2080644501 hasConceptScore W2080644501C2780841215 @default.
• W2080644501 hasConceptScore W2080644501C2781063702 @default.
• W2080644501 hasConceptScore W2080644501C2781085546 @default.
• W2080644501 hasConceptScore W2080644501C3675279 @default.
• W2080644501 hasConceptScore W2080644501C55493867 @default.
• W2080644501 hasConceptScore W2080644501C71924100 @default.
• W2080644501 hasConceptScore W2080644501C86803240 @default.
• W2080644501 hasIssue "6" @default.
• W2080644501 hasLocation W20806445011 @default.

• next