FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080644862> ?p ?o ?g. }

• W2080644862 endingPage "11" @default.
• W2080644862 startingPage "5" @default.
• W2080644862 abstract "Photoimmunotherapy (PIT) is based on the use of a monoclonal antibody specific to cancer epitopes conjugated to a photosensitizer near-infrared phthalocyanine dye (IR700). In this study, PIT with IR700 conjugated to anti-carcinoembryonic antigen (CEA) was used as an adjunct to surgery in orthotopically-implanted human pancreatic cancer in a nude mouse model to eliminate microscopic disease in the post-surgical tumor bed and prevent local as well as metastatic recurrence.Athymic nude mice were orthotopically implanted with the human pancreatic cancer cell line BxPC3 expressing green fluorescent protein. After tumor engraftment, the mice were divided into two groups as follows: bright light surgery (BLS) + anti-CEA-IR700 + 690 nm laser (PIT); and BLS only. Anti-CEA-IR700 (100 μg) was administered to the treatment group via tail-vein injection 24 h before therapy. Tumors were resected, and the surgical bed was treated with intraoperative phototherapy at an intensity of 150 mW/cm(2) for 30 min. Mice were imaged noninvasively for 8 wk using an OV-100 small animal fluorescence imager.BLS + PIT reduced local recurrence to 1/7 mice from 7/7 mice with BLS-only (P = 0.001) and metastatic recurrence to 2/7 mice compared with 6/7 mice with BLS-only (P = 0.03). Local tumor growth continued at a rapid rate after BLS-only compared with BLS + PIT where almost no local growth occurred. There was a significant difference in tumor size between mice in the BLS + PIT (2.14 mm(2), 95% confidence interval [CI] [-2.06 to 6.34] and BLS-only groups (115.2 mm(2), 95% CI [88.8-141.6]) at 6 wk after surgery (P < 0.001). There was also a significant difference in tumor weight between the BLS + PIT group (6.65 mg, 95% CI [-6.35 to 19.65] and BLS-only group (1100 mg, 95% CI [794-1406] at 8 wk after surgery (P < 0.001).PIT holds promise in the treatment of pancreatic cancer and may serve as a useful adjunct to surgery in the eradication of microscopic residual disease that can lead to both local and metastatic recurrence. Further studies are warranted to investigate the potential toxicities of PIT, especially with regard to anastomoses, such as those involved in pancreaticoduodenectomy." @default.
• W2080644862 created "2016-06-24" @default.
• W2080644862 creator A5009960666 @default.
• W2080644862 creator A5010474061 @default.
• W2080644862 creator A5025597945 @default.
• W2080644862 creator A5040819666 @default.
• W2080644862 creator A5047702051 @default.
• W2080644862 creator A5064222660 @default.
• W2080644862 creator A5066816769 @default.
• W2080644862 creator A5090173640 @default.
• W2080644862 date "2015-07-01" @default.
• W2080644862 modified "2023-10-04" @default.
• W2080644862 title "Photoimmunotherapy lowers recurrence after pancreatic cancer surgery in orthotopic nude mouse models" @default.
• W2080644862 cites W1520675461 @default.
• W2080644862 cites W1569875761 @default.
• W2080644862 cites W1641731707 @default.
• W2080644862 cites W1655333672 @default.
• W2080644862 cites W1969705513 @default.
• W2080644862 cites W1972684058 @default.
• W2080644862 cites W1977831949 @default.
• W2080644862 cites W1983692618 @default.
• W2080644862 cites W2000844719 @default.
• W2080644862 cites W2004583224 @default.
• W2080644862 cites W2005089069 @default.
• W2080644862 cites W2008999855 @default.
• W2080644862 cites W2017000798 @default.
• W2080644862 cites W2017045575 @default.
• W2080644862 cites W2017379383 @default.
• W2080644862 cites W2022097554 @default.
• W2080644862 cites W2032870724 @default.
• W2080644862 cites W2045277166 @default.
• W2080644862 cites W2046367925 @default.
• W2080644862 cites W2050753051 @default.
• W2080644862 cites W2089627656 @default.
• W2080644862 cites W2104644172 @default.
• W2080644862 cites W2116580445 @default.
• W2080644862 cites W2123002159 @default.
• W2080644862 cites W347202097 @default.
• W2080644862 cites W4229719081 @default.
• W2080644862 doi "https://doi.org/10.1016/j.jss.2015.02.037" @default.
• W2080644862 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4457622" @default.
• W2080644862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25799527" @default.
• W2080644862 hasPublicationYear "2015" @default.
• W2080644862 type Work @default.
• W2080644862 sameAs 2080644862 @default.
• W2080644862 citedByCount "27" @default.
• W2080644862 countsByYear W20806448622015 @default.
• W2080644862 countsByYear W20806448622016 @default.
• W2080644862 countsByYear W20806448622017 @default.
• W2080644862 countsByYear W20806448622018 @default.
• W2080644862 countsByYear W20806448622019 @default.
• W2080644862 countsByYear W20806448622020 @default.
• W2080644862 countsByYear W20806448622021 @default.
• W2080644862 countsByYear W20806448622022 @default.
• W2080644862 countsByYear W20806448622023 @default.
• W2080644862 crossrefType "journal-article" @default.
• W2080644862 hasAuthorship W2080644862A5009960666 @default.
• W2080644862 hasAuthorship W2080644862A5010474061 @default.
• W2080644862 hasAuthorship W2080644862A5025597945 @default.
• W2080644862 hasAuthorship W2080644862A5040819666 @default.
• W2080644862 hasAuthorship W2080644862A5047702051 @default.
• W2080644862 hasAuthorship W2080644862A5064222660 @default.
• W2080644862 hasAuthorship W2080644862A5066816769 @default.
• W2080644862 hasAuthorship W2080644862A5090173640 @default.
• W2080644862 hasBestOaLocation W20806448622 @default.
• W2080644862 hasConcept C121608353 @default.
• W2080644862 hasConcept C126322002 @default.
• W2080644862 hasConcept C126894567 @default.
• W2080644862 hasConcept C141071460 @default.
• W2080644862 hasConcept C142724271 @default.
• W2080644862 hasConcept C159654299 @default.
• W2080644862 hasConcept C178790620 @default.
• W2080644862 hasConcept C185592680 @default.
• W2080644862 hasConcept C203014093 @default.
• W2080644862 hasConcept C2776694085 @default.
• W2080644862 hasConcept C2777387746 @default.
• W2080644862 hasConcept C2780210213 @default.
• W2080644862 hasConcept C2780278673 @default.
• W2080644862 hasConcept C2781469039 @default.
• W2080644862 hasConcept C542903549 @default.
• W2080644862 hasConcept C71924100 @default.
• W2080644862 hasConceptScore W2080644862C121608353 @default.
• W2080644862 hasConceptScore W2080644862C126322002 @default.
• W2080644862 hasConceptScore W2080644862C126894567 @default.
• W2080644862 hasConceptScore W2080644862C141071460 @default.
• W2080644862 hasConceptScore W2080644862C142724271 @default.
• W2080644862 hasConceptScore W2080644862C159654299 @default.
• W2080644862 hasConceptScore W2080644862C178790620 @default.
• W2080644862 hasConceptScore W2080644862C185592680 @default.
• W2080644862 hasConceptScore W2080644862C203014093 @default.
• W2080644862 hasConceptScore W2080644862C2776694085 @default.
• W2080644862 hasConceptScore W2080644862C2777387746 @default.
• W2080644862 hasConceptScore W2080644862C2780210213 @default.
• W2080644862 hasConceptScore W2080644862C2780278673 @default.
• W2080644862 hasConceptScore W2080644862C2781469039 @default.
• W2080644862 hasConceptScore W2080644862C542903549 @default.
• W2080644862 hasConceptScore W2080644862C71924100 @default.
• W2080644862 hasFunder F4320337351 @default.

• next