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• W2080645938 abstract "Exposure of frog toe muscles to 1 mM La 3+ results in a decrease in amplitude and rate of tension development of potassium contractures and twitches. At this concentration La 3+ also inhibits the uptake of calcium, both in the resting condition and during stimulation. Caffeine contractures are unaffected even after a 5-min pre-exposure to La 3+ . The depolarization induced by various concentrations of K + is reduced by about 10 mV as is the amplitude of the action potential. The rate of rise of the action potential is reduced by about 40% after 1 min in La 3+ Ringer. Neither the decreased amplitude nor the reduced rate of depolarization is considered to be sufficient to explain the inhibition of tension development. It is suggested that La 3+ partially uncouples excitation from contraction by preventing the release of a trigger-Ca 2+ fraction from some site on the muscle membrane. This fraction normally plays a role in excitation–contraction coupling, although some tension may still be developed in the absence of a trigger-Ca 2+ influx." @default.
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• W2080645938 date "1974-12-01" @default.
• W2080645938 modified "2023-10-18" @default.
• W2080645938 title "The Effect of Lanthanum on Excitation–Contraction Coupling in Frog Skeletal Muscle" @default.
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• W2080645938 doi "https://doi.org/10.1139/y74-148" @default.
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