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- W2080646532 abstract "Leukocytes have been implicated in myocardial infarction (MI) development and progression. We tested the efficacy of the novel leukocyte recruitment inhibitor NPC 15669 (Scios Nova, Inc.) on myocardial stunning (MS) and preconditioned MI. NPC is a member of the leumedins, and is an inhibitor of leukocyte adhesion to endothelium via blockage of integrin binding. We also show, that NPC 15669 have strong antiplatelet effects. In an open chested swine model, NPC 15669 (10 mg NPC/kg loading dose followed by constant infusion at 6 mg/kg -1 /h -l )was administered in 6 animals. Myocardial thickening (MT) was determined by epicardial ultrasound. The left anterior descending artery was occluded for 8 min. followed by 90 min. of reperfusion, during which myocardial MT was recorded at regular intervals. We have found that treatment with NPC 15669 increases myocardial contractility and significantly decreases MS time compared to six controls (26.7 ± 4.0 min vs. 50.0 ± 4.3 min, p = 0.0026). This report also demonstrates the beneficial effects of NPC 15669 on myocardial tissue survival after a period of ischemia. In NPC 15669 treated animals 23.4 ± 6.7% of at risk tissue became necrotic compared to 53.0 ± 6.6% in controls, p = 0.0102. Our data suggests that NPC 15669 significantly reduces myocardial injury in both the stunning and infarction mod els. The precise mechanism of these effects is unknown, but may be related to the inhibition of platelet function and/or leukocyte recruitment." @default.
- W2080646532 created "2016-06-24" @default.
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- W2080646532 date "1995-02-01" @default.
- W2080646532 modified "2023-09-27" @default.
- W2080646532 title "931-110 Effects of NPC 15669 on Myocardial Stunning and Infarction Size" @default.
- W2080646532 doi "https://doi.org/10.1016/0735-1097(95)91938-t" @default.
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