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- W2080646593 abstract "The mastermind locus encodes a nuclear protein required in the Notch signalling pathway. In a screen for genes affecting wing pattern, we identified an EP element that directs expression of an alternatively spliced form of the mastermind transcript that we call mam[DN]. Unlike the conventional mam transcript, mam[DN] is spatially regulated in the developing embryonic nervous system and eye imaginal disc. mam[DN] corresponds to an endogenous transcript and encodes an alternate form of the Mam protein that dominantly interferes with activity of the conventional Mam protein. Mam[DN] blocks Notch signalling downstream from the activated form of Notch but cannot interfere with an activated form of Su(H), suggesting that Mam[DN] may interfere with the activity of a ternary complex involving Mam, Notch and Su(H)." @default.
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- W2080646593 date "2002-07-01" @default.
- W2080646593 modified "2023-10-11" @default.
- W2080646593 title "A naturally occurring alternative product of the mastermind locus that represses notch signalling" @default.
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- W2080646593 doi "https://doi.org/10.1016/s0925-4773(02)00124-7" @default.
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