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- W2080646606 abstract "Changes in intraocular pressure (IOP) and pupil diameter were studied in albino rabbits following topical administration of TL-99, M-7 (N,N-dimethyl analogues of 2-aminotetralin), DiPr-5,6-ADTN, DiPr-6,7-ADTN (dipropyl analogues of aminotetralin) and DPDA (N,N-di-n-propyl-dopamine), known as mixed alpha-adrenoceptor/dopamine receptor agonists with variable alpha 1/alpha 2-adrenoceptor/selectivity. The potencies of those compounds to decrease IOP were compared with each other. We found that M-7 has the most potent IOP-lowering properties, caused minimal ocular discomfort and is of interest as a potential antiglaucoma agent. The ocular hypotension was completely inhibited by rauwolscine and slightly antagonized by various other blocking agents. The results strongly suggest that the IOP-lowering effect of M-7 is mediated by the stimulation of alpha 2-adrenoceptors." @default.
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- W2080646606 date "1985-01-01" @default.
- W2080646606 modified "2023-10-16" @default.
- W2080646606 title "M-7 Lowers Rabbit Intraocular Pressure" @default.
- W2080646606 doi "https://doi.org/10.1159/000265402" @default.
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