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• W2080647684 abstract "The 23 amino acid-long extracellular domain of the influenza virus transmembrane protein M2 (M2e) has remained highly conserved since the 1918 pandemic, and is thus considered a good candidate for development of a universal influenza A vaccine. However, M2e is poorly immunogenic. In this study we assessed the potential of increasing immunogenicity of M2e by constructing a nanoscale-designed protein polymer containing the M2e sequence and an elastin-like polypeptide (ELP) nanodomain consisting of alanine and tyrosine guest residues (ELP(A 2 YA 2 ) 24 ). The ELP nanodomain was included to increase antigen size, and to exploit the inherent thermal inverse phase transition behavior of ELPs to purify the protein polymer. The ELP(A 2 YA 2 ) 24 + M2e nanodomained molecule was recombinantly synthesized. Characterization of its inverse phase transition behavior demonstrated that attachment of M2e to ELP(A 2 YA 2 ) 24 increased its transition temperature compared to ELP(A 2 YA 2 ) 24 . Using a dot blot test we determined that M2e conjugated to ELP is recognizable by M2e-specific antibodies, suggesting that the conjugation process does not adversely affect the immunogenic property of M2e. Further, upon vaccinating mice with ELP(A 2 YA 2 ) 24 + M2e it was found that indeed the nanodomained protein enhanced M2e-specific antibodies in mouse serum compared to free M2e peptide and ELP(A 2 YA 2 ) 24 . The immune serum could also recognize M2 expressed on influenza virions. Overall, this data suggests the potential of using molecules containing M2e-ELP nanodomains to develop a universal influenza vaccine." @default.
• W2080647684 created "2016-06-24" @default.
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• W2080647684 date "2014-06-01" @default.
• W2080647684 modified "2023-10-15" @default.
• W2080647684 title "Synthesis and Immunogenicity Assessment of Elastin-Like Polypeptide-M2e Construct as an Influenza Antigen" @default.
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• W2080647684 doi "https://doi.org/10.1142/s1793984414500044" @default.
• W2080647684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4376021" @default.
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• W2080647684 hasPublicationYear "2014" @default.
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