FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080649426> ?p ?o ?g. }

• W2080649426 endingPage "331" @default.
• W2080649426 startingPage "325" @default.
• W2080649426 abstract "Background: Integrin α4β7 (α4β7) mediates the homing of CD4+ T cells to gut-associated lymphoid tissues, which constitute a highly favorable environment for HIV expansion and dissemination. HIV and simian immunodeficiency virus (SIV) envelope proteins bind to and signal through α4β7 and during acute infection SIV preferentially infects α4β7high CD4+ T cells. We postulated that the availability of these cells at the time of challenge could influence mucosal SIV transmission and acute viral load (VL). Methods: We challenged 17 rhesus macaques with 3000 TCID50 of SIVmac239 rectally and followed the subsets of α4β7+ T cells and dendritic cells (DCs) by flow cytometry in blood and tissues, before and after challenge. Results: We found that the frequency of memory CD4+ T cells that expressed high levels of α4β7 (α4β7high memory CD4+ T cells) in blood before challenge correlated strongly with susceptibility to infection and acute VL. Notably, not only at the time of challenge but also their frequency 3 weeks before challenge correlated with infection. This association extended to the rectal tissue as we observed a strong direct correlation between the frequency of α4β7high memory CD4+ T cells in blood and rectum before and after challenge. The frequency of α4β7+ myeloid DCs and α4β7high CD80+ DCs also correlated with infection and acute VL, whereas blood CCR5+ and CD69+ CD4+ T cells could not be associated with infection. Conclusions: Our results suggest that animals with higher frequency of α4β7high CD4+ T cells in circulation and in rectal tissue could be more susceptible to SIV rectal transmission." @default.
• W2080649426 created "2016-06-24" @default.
• W2080649426 creator A5017827760 @default.
• W2080649426 creator A5022406235 @default.
• W2080649426 creator A5035288578 @default.
• W2080649426 creator A5038068474 @default.
• W2080649426 creator A5043225490 @default.
• W2080649426 creator A5054518780 @default.
• W2080649426 creator A5055778782 @default.
• W2080649426 creator A5069359815 @default.
• W2080649426 creator A5087451794 @default.
• W2080649426 creator A5089579849 @default.
• W2080649426 creator A5090958074 @default.
• W2080649426 date "2013-12-01" @default.
• W2080649426 modified "2023-10-17" @default.
• W2080649426 title "The Frequency of α4β7 high Memory CD4+ T Cells Correlates With Susceptibility to Rectal Simian Immunodeficiency Virus Infection" @default.
• W2080649426 cites W1534793353 @default.
• W2080649426 cites W1756041634 @default.
• W2080649426 cites W1976632658 @default.
• W2080649426 cites W1981459523 @default.
• W2080649426 cites W1984999783 @default.
• W2080649426 cites W1989222449 @default.
• W2080649426 cites W1998515468 @default.
• W2080649426 cites W2002574877 @default.
• W2080649426 cites W2002915050 @default.
• W2080649426 cites W2009567395 @default.
• W2080649426 cites W2011475847 @default.
• W2080649426 cites W2021999210 @default.
• W2080649426 cites W2040026254 @default.
• W2080649426 cites W2051200921 @default.
• W2080649426 cites W2062876702 @default.
• W2080649426 cites W2066754037 @default.
• W2080649426 cites W2077781959 @default.
• W2080649426 cites W2078489697 @default.
• W2080649426 cites W2078838277 @default.
• W2080649426 cites W2084533546 @default.
• W2080649426 cites W2096515408 @default.
• W2080649426 cites W2114328141 @default.
• W2080649426 cites W2117450920 @default.
• W2080649426 cites W2119835296 @default.
• W2080649426 cites W2131915942 @default.
• W2080649426 cites W2133956851 @default.
• W2080649426 cites W2142888951 @default.
• W2080649426 cites W2145924660 @default.
• W2080649426 cites W2146672876 @default.
• W2080649426 cites W2157981287 @default.
• W2080649426 cites W2159593123 @default.
• W2080649426 cites W2165426812 @default.
• W2080649426 cites W2395728031 @default.
• W2080649426 doi "https://doi.org/10.1097/qai.0b013e31829f6e1a" @default.
• W2080649426 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3815485" @default.
• W2080649426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23797688" @default.
• W2080649426 hasPublicationYear "2013" @default.
• W2080649426 type Work @default.
• W2080649426 sameAs 2080649426 @default.
• W2080649426 citedByCount "53" @default.
• W2080649426 countsByYear W20806494262014 @default.
• W2080649426 countsByYear W20806494262015 @default.
• W2080649426 countsByYear W20806494262016 @default.
• W2080649426 countsByYear W20806494262017 @default.
• W2080649426 countsByYear W20806494262018 @default.
• W2080649426 countsByYear W20806494262019 @default.
• W2080649426 countsByYear W20806494262020 @default.
• W2080649426 countsByYear W20806494262021 @default.
• W2080649426 countsByYear W20806494262022 @default.
• W2080649426 crossrefType "journal-article" @default.
• W2080649426 hasAuthorship W2080649426A5017827760 @default.
• W2080649426 hasAuthorship W2080649426A5022406235 @default.
• W2080649426 hasAuthorship W2080649426A5035288578 @default.
• W2080649426 hasAuthorship W2080649426A5038068474 @default.
• W2080649426 hasAuthorship W2080649426A5043225490 @default.
• W2080649426 hasAuthorship W2080649426A5054518780 @default.
• W2080649426 hasAuthorship W2080649426A5055778782 @default.
• W2080649426 hasAuthorship W2080649426A5069359815 @default.
• W2080649426 hasAuthorship W2080649426A5087451794 @default.
• W2080649426 hasAuthorship W2080649426A5089579849 @default.
• W2080649426 hasAuthorship W2080649426A5090958074 @default.
• W2080649426 hasBestOaLocation W20806494261 @default.
• W2080649426 hasConcept C142462285 @default.
• W2080649426 hasConcept C154317977 @default.
• W2080649426 hasConcept C159047783 @default.
• W2080649426 hasConcept C167672396 @default.
• W2080649426 hasConcept C202751555 @default.
• W2080649426 hasConcept C203014093 @default.
• W2080649426 hasConcept C2522874641 @default.
• W2080649426 hasConcept C2777995582 @default.
• W2080649426 hasConcept C55493867 @default.
• W2080649426 hasConcept C86803240 @default.
• W2080649426 hasConcept C8891405 @default.
• W2080649426 hasConceptScore W2080649426C142462285 @default.
• W2080649426 hasConceptScore W2080649426C154317977 @default.
• W2080649426 hasConceptScore W2080649426C159047783 @default.
• W2080649426 hasConceptScore W2080649426C167672396 @default.
• W2080649426 hasConceptScore W2080649426C202751555 @default.
• W2080649426 hasConceptScore W2080649426C203014093 @default.
• W2080649426 hasConceptScore W2080649426C2522874641 @default.
• W2080649426 hasConceptScore W2080649426C2777995582 @default.
• W2080649426 hasConceptScore W2080649426C55493867 @default.

• next