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• W2080654306 abstract "It frequently has been postulated that intersexual coevolution between the male ejaculate and the female reproductive tract is a driving force in the rapid evolution of reproductive proteins. The dearth of research on female tracts, however, presents a major obstacle to empirical tests of this hypothesis. Here, we employ a comparative EST approach to identify 241 candidate female reproductive proteins in Drosophila arizonae, a repleta group species in which physiological ejaculate–female coevolution has been documented. Thirty-one of these proteins exhibit elevated amino acid substitution rates, making them candidates for molecular coevolution with the male ejaculate. Strikingly, we also discovered 12 unique digestive proteases whose expression is specific to the D. arizonae lower female reproductive tract. These enzymes belong to classes most commonly found in the gastrointestinal tracts of a diverse array of organisms. We show that these proteases are associated with recent, lineage-specific gene duplications in the Drosophila repleta species group, and exhibit strong signatures of positive selection. Observation of adaptive evolution in several female reproductive tract proteins indicates they are active players in the evolution of reproductive tract interactions. Additionally, pervasive gene duplication, adaptive evolution, and rapid acquisition of a novel digestive function by the female reproductive tract points to a novel coevolutionary mechanism of ejaculate–female interaction." @default.
• W2080654306 created "2016-06-24" @default.
• W2080654306 creator A5032158361 @default.
• W2080654306 creator A5037906191 @default.
• W2080654306 creator A5044018179 @default.
• W2080654306 date "2007-08-31" @default.
• W2080654306 modified "2023-10-17" @default.
• W2080654306 title "Gene Duplication and Adaptive Evolution of Digestive Proteases in Drosophila arizonae Female Reproductive Tracts" @default.
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• W2080654306 doi "https://doi.org/10.1371/journal.pgen.0030148" @default.
• W2080654306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1959364" @default.
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• W2080654306 hasPublicationYear "2007" @default.
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