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- W2080661641 endingPage "1531" @default.
- W2080661641 startingPage "1521" @default.
- W2080661641 abstract "Adenovirus (Ad)-based vectors offer several benefits showing their potential for use in a variety of vaccine applications. Recombinant Ad-based vaccines possess potent immunogenic potential, capable of generating humoral and cellular immune responses to a variety of pathogen-specific antigens expressed by the vectors. Ad5 vectors can be readily produced, allowing for usage in thousands of clinical trial subjects. This is now coupled with a history of safe clinical use in the vaccine setting. However, traditional Ad5-based vaccines may not be generating optimal antigen-specific immune responses, and generate diminished antigen-specific immune responses when pre-existing Ad5 immunity is present. These limitations have driven initiation of several approaches to improve the efficacy of Ad-based vaccines, and/or allow modified vaccines to overcome pre-existing Ad immunity. These include: generation of chemically modified Ad5 capsids; generation of chimeric Ads; complete replacement of Ad5-based vaccine platforms with alternative (human and non-human origin) Ad serotypes, and Ad5 genome modification approaches that attempt to retain the native Ad5 capsid, while simultaneously improving the efficacy of the platform as well as minimizing the effect of pre-existing Ad immunity. Here we discuss recent advances in- and limitations of each of these approaches, relative to their abilities to overcome pre-existing Ad immunity." @default.
- W2080661641 created "2016-06-24" @default.
- W2080661641 creator A5016155646 @default.
- W2080661641 creator A5083266436 @default.
- W2080661641 date "2009-09-28" @default.
- W2080661641 modified "2023-10-06" @default.
- W2080661641 title "Overcoming pre-existing adenovirus immunity by genetic engineering of adenovirus-based vectors" @default.
- W2080661641 cites W1550346644 @default.
- W2080661641 cites W1577731904 @default.
- W2080661641 cites W1586130277 @default.
- W2080661641 cites W1590390236 @default.
- W2080661641 cites W189956990 @default.
- W2080661641 cites W1913924834 @default.
- W2080661641 cites W1924636867 @default.
- W2080661641 cites W1971233211 @default.
- W2080661641 cites W1971460945 @default.
- W2080661641 cites W1972583528 @default.
- W2080661641 cites W1975752974 @default.
- W2080661641 cites W1979989636 @default.
- W2080661641 cites W1980486105 @default.
- W2080661641 cites W1982794080 @default.
- W2080661641 cites W1982805293 @default.
- W2080661641 cites W1983993040 @default.
- W2080661641 cites W1984376606 @default.
- W2080661641 cites W1988115863 @default.
- W2080661641 cites W1990978997 @default.
- W2080661641 cites W1995350396 @default.
- W2080661641 cites W1998150791 @default.
- W2080661641 cites W1998630678 @default.
- W2080661641 cites W1999768026 @default.
- W2080661641 cites W1999982139 @default.
- W2080661641 cites W2003320929 @default.
- W2080661641 cites W2004497415 @default.
- W2080661641 cites W2007276010 @default.
- W2080661641 cites W2008260185 @default.
- W2080661641 cites W2012445117 @default.
- W2080661641 cites W2013756986 @default.
- W2080661641 cites W2018628417 @default.
- W2080661641 cites W2021854607 @default.
- W2080661641 cites W2024189842 @default.
- W2080661641 cites W2025996762 @default.
- W2080661641 cites W2029445351 @default.
- W2080661641 cites W2030404196 @default.
- W2080661641 cites W2033489818 @default.
- W2080661641 cites W2034106065 @default.
- W2080661641 cites W2036825103 @default.
- W2080661641 cites W2040980661 @default.
- W2080661641 cites W2041142673 @default.
- W2080661641 cites W2044338251 @default.
- W2080661641 cites W2047771618 @default.
- W2080661641 cites W2048927678 @default.
- W2080661641 cites W2051108441 @default.
- W2080661641 cites W2052971734 @default.
- W2080661641 cites W2067174610 @default.
- W2080661641 cites W2068000460 @default.
- W2080661641 cites W2071710058 @default.
- W2080661641 cites W2074302783 @default.
- W2080661641 cites W2075953769 @default.
- W2080661641 cites W2078519091 @default.
- W2080661641 cites W2080094805 @default.
- W2080661641 cites W2084231715 @default.
- W2080661641 cites W2084648294 @default.
- W2080661641 cites W2087244642 @default.
- W2080661641 cites W2090509556 @default.
- W2080661641 cites W2090851055 @default.
- W2080661641 cites W2091089019 @default.
- W2080661641 cites W2091843601 @default.
- W2080661641 cites W2092960442 @default.
- W2080661641 cites W2093193202 @default.
- W2080661641 cites W2093314947 @default.
- W2080661641 cites W2097869227 @default.
- W2080661641 cites W2098617460 @default.
- W2080661641 cites W2102648190 @default.
- W2080661641 cites W2104172028 @default.
- W2080661641 cites W2105260144 @default.
- W2080661641 cites W2105352387 @default.
- W2080661641 cites W2106634937 @default.
- W2080661641 cites W2110654860 @default.
- W2080661641 cites W2111108128 @default.
- W2080661641 cites W2117165165 @default.
- W2080661641 cites W2121429345 @default.
- W2080661641 cites W2127481689 @default.
- W2080661641 cites W2130451879 @default.
- W2080661641 cites W2133822846 @default.
- W2080661641 cites W2133957204 @default.
- W2080661641 cites W2137440275 @default.
- W2080661641 cites W2138382635 @default.
- W2080661641 cites W2139130466 @default.
- W2080661641 cites W2142271305 @default.
- W2080661641 cites W2142579851 @default.
- W2080661641 cites W2148123079 @default.
- W2080661641 cites W2151130810 @default.
- W2080661641 cites W2152744762 @default.
- W2080661641 cites W2153670011 @default.
- W2080661641 cites W2154334620 @default.
- W2080661641 cites W2154853039 @default.
- W2080661641 cites W2156487862 @default.
- W2080661641 cites W2163787552 @default.