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- W2080661875 abstract "To the Editor: Trastuzumab, an antibody against the protein product of the human epidermal growth factor receptor type 2 (HER2) gene, improves progression-free survival and overall survival when added to chemotherapy in patients with metastatic breast cancer.1 Initial trials enrolled patients with tumors that had a staining intensity of 2+ or 3+ for HER2 on immunohistochemical analysis, but in subsequent studies, the benefit was limited to tumors with HER2 amplification as determined by fluorescence in situ hybridization (FISH). Trastuzumab also improves disease-free survival and overall survival in the adjuvant setting.2 On the basis of its mechanism of action, . . ." @default.
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- W2080661875 date "2008-03-27" @default.
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- W2080661875 title "<i>HER2</i>Status and Benefit from Adjuvant Trastuzumab in Breast Cancer" @default.
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- W2080661875 doi "https://doi.org/10.1056/nejmc0801440" @default.
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