FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080666240> ?p ?o ?g. }

• W2080666240 endingPage "1837" @default.
• W2080666240 startingPage "1832" @default.
• W2080666240 abstract "Diverse cellular stress responses are linked to phosphorylation of serine 51 on the alpha subunit of translation initiation factor 2. The resultant attenuation of protein synthesis and activation of gene expression figure heavily in the adaptive response to stress, but dephosphorylation of eIF2(αP), which terminates signaling in this pathway, is less well understood. GADD34 and CReP, the products of the related mammalian genes Ppp1r15a and Ppp1r15b , can recruit phosphatase catalytic subunits of the PPP1 class to eIF2(αP), but the significance of their contribution to its dephosphorylation has not been explored systematically. Here we report that unlike Ppp1r15a mutant mice, which are superficially indistinguishable from wild type, Ppp1r15b −/− mouse embryos survive gestation but exhibit severe growth retardation and impaired erythropoiesis, and loss of both Ppp1r15 genes leads to early embryonic lethality. These loss-of-function phenotypes are rescued by a mutation, Eif2a S51A , that prevents regulated phosphorylation of eIF2α. These findings reveal that the essential process of eIF2(αP) dephosphorylation is the predominant role of PPP1R15 proteins in mammalian development." @default.
• W2080666240 created "2016-06-24" @default.
• W2080666240 creator A5007631856 @default.
• W2080666240 creator A5010360422 @default.
• W2080666240 creator A5015378855 @default.
• W2080666240 creator A5077934127 @default.
• W2080666240 creator A5081084192 @default.
• W2080666240 creator A5088486032 @default.
• W2080666240 date "2009-02-10" @default.
• W2080666240 modified "2023-10-11" @default.
• W2080666240 title "Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development" @default.
• W2080666240 cites W1522883299 @default.
• W2080666240 cites W1964034369 @default.
• W2080666240 cites W1967715001 @default.
• W2080666240 cites W1972482541 @default.
• W2080666240 cites W1989129860 @default.
• W2080666240 cites W1992537746 @default.
• W2080666240 cites W1993431258 @default.
• W2080666240 cites W2012695878 @default.
• W2080666240 cites W2020912852 @default.
• W2080666240 cites W2021207380 @default.
• W2080666240 cites W2024591653 @default.
• W2080666240 cites W2028866472 @default.
• W2080666240 cites W2036791863 @default.
• W2080666240 cites W2053593146 @default.
• W2080666240 cites W2069646782 @default.
• W2080666240 cites W2071700771 @default.
• W2080666240 cites W2076131270 @default.
• W2080666240 cites W2076153728 @default.
• W2080666240 cites W2077784911 @default.
• W2080666240 cites W2082873063 @default.
• W2080666240 cites W2093158584 @default.
• W2080666240 cites W2100472948 @default.
• W2080666240 cites W2102839649 @default.
• W2080666240 cites W2110420807 @default.
• W2080666240 cites W2116233369 @default.
• W2080666240 cites W2118337893 @default.
• W2080666240 cites W2119902047 @default.
• W2080666240 cites W2128600167 @default.
• W2080666240 cites W2139529165 @default.
• W2080666240 cites W2139568257 @default.
• W2080666240 cites W2140487984 @default.
• W2080666240 cites W2141030634 @default.
• W2080666240 cites W2156990953 @default.
• W2080666240 cites W2160414774 @default.
• W2080666240 cites W4254493498 @default.
• W2080666240 doi "https://doi.org/10.1073/pnas.0809632106" @default.
• W2080666240 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2644123" @default.
• W2080666240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19181853" @default.
• W2080666240 hasPublicationYear "2009" @default.
• W2080666240 type Work @default.
• W2080666240 sameAs 2080666240 @default.
• W2080666240 citedByCount "215" @default.
• W2080666240 countsByYear W20806662402012 @default.
• W2080666240 countsByYear W20806662402013 @default.
• W2080666240 countsByYear W20806662402014 @default.
• W2080666240 countsByYear W20806662402015 @default.
• W2080666240 countsByYear W20806662402016 @default.
• W2080666240 countsByYear W20806662402017 @default.
• W2080666240 countsByYear W20806662402018 @default.
• W2080666240 countsByYear W20806662402019 @default.
• W2080666240 countsByYear W20806662402020 @default.
• W2080666240 countsByYear W20806662402021 @default.
• W2080666240 countsByYear W20806662402022 @default.
• W2080666240 countsByYear W20806662402023 @default.
• W2080666240 crossrefType "journal-article" @default.
• W2080666240 hasAuthorship W2080666240A5007631856 @default.
• W2080666240 hasAuthorship W2080666240A5010360422 @default.
• W2080666240 hasAuthorship W2080666240A5015378855 @default.
• W2080666240 hasAuthorship W2080666240A5077934127 @default.
• W2080666240 hasAuthorship W2080666240A5081084192 @default.
• W2080666240 hasAuthorship W2080666240A5088486032 @default.
• W2080666240 hasBestOaLocation W20806662402 @default.
• W2080666240 hasConcept C104317684 @default.
• W2080666240 hasConcept C105580179 @default.
• W2080666240 hasConcept C11960822 @default.
• W2080666240 hasConcept C149364088 @default.
• W2080666240 hasConcept C178666793 @default.
• W2080666240 hasConcept C181912034 @default.
• W2080666240 hasConcept C2779638656 @default.
• W2080666240 hasConcept C54355233 @default.
• W2080666240 hasConcept C86803240 @default.
• W2080666240 hasConcept C93734116 @default.
• W2080666240 hasConcept C95444343 @default.
• W2080666240 hasConceptScore W2080666240C104317684 @default.
• W2080666240 hasConceptScore W2080666240C105580179 @default.
• W2080666240 hasConceptScore W2080666240C11960822 @default.
• W2080666240 hasConceptScore W2080666240C149364088 @default.
• W2080666240 hasConceptScore W2080666240C178666793 @default.
• W2080666240 hasConceptScore W2080666240C181912034 @default.
• W2080666240 hasConceptScore W2080666240C2779638656 @default.
• W2080666240 hasConceptScore W2080666240C54355233 @default.
• W2080666240 hasConceptScore W2080666240C86803240 @default.
• W2080666240 hasConceptScore W2080666240C93734116 @default.
• W2080666240 hasConceptScore W2080666240C95444343 @default.
• W2080666240 hasIssue "6" @default.
• W2080666240 hasLocation W20806662401 @default.
• W2080666240 hasLocation W20806662402 @default.

• next