FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080666971> ?p ?o ?g. }

• W2080666971 endingPage "275" @default.
• W2080666971 startingPage "265" @default.
• W2080666971 abstract "It has previously been shown that dietary copper can modulate the extent of atherosclerosis in the thoracic aorta of cholesterol-fed rabbits. The metabolism of copper and zinc are closely related, and it has been hypothesized that the balance of dietary copper to zinc may be important in determining coronary risk. Hence, we have investigated the interaction between dietary copper and zinc in atherogenesis in the New Zealand White rabbit. Juvenile male rabbits were randomly allocated to eight groups. Four groups were fed a normal chow diet with zinc (0.5%, w/w), copper (0.2%, w/w), copper plus zinc or neither in their drinking water for 12 weeks. Four other groups were fed a diet containing 0.25–1% (w/w) cholesterol plus zinc, copper, both or neither. Serum cholesterol of individual animals was maintained at approximately 20 mmol/l. Integrated plasma cholesterol levels were similar for all groups receiving cholesterol and significantly higher than those in the chow-fed groups (P < 0.001). Aortic copper concentrations were higher in the animals receiving cholesterol diets with copper compared to rabbits receiving normal chow and copper (P < 0.001). Aortic zinc content was significantly higher in cholesterol-fed rabbits supplemented with zinc alone or with copper than in those fed cholesterol alone (P < 0.001). Plasma ceruloplasmin concentrations were significantly higher in groups receiving cholesterol, irrespective of their trace element supplementation (P < 0.001). However, trace element supplementation increased the level significantly (P < 0.05). Trace element supplements did not appear to affect erythrocyte superoxide dismutase in the cholesterol-fed animals; however, zinc supplementation was associated with a significant increase in the enzyme in chow-fed animals (P < 0.05). The activity of the enzyme per mg of protein in aortic tissue was higher in animals receiving copper in the presence of cholesterol (P < 0.05) but not significantly so in its absence. Dietary trace element supplementation in cholesterol-fed animals was associated with a significant reduction in aortic lesion area. Plasma thiobarbituric acid-reactive substances and FOX concentrations were both significantly higher in the cholesterol-fed rabbits compared with the animals that fed on a chow diet (P < 0.001), and these were reduced significantly by dietary copper or zinc supplementation (P < 0.001). Hence, dietary supplements of copper or zinc at the doses used both inhibited aortic atherogenesis in the cholesterol-fed rabbits, although there was no significant additional effect when given in combination." @default.
• W2080666971 created "2016-06-24" @default.
• W2080666971 creator A5026005703 @default.
• W2080666971 creator A5038854437 @default.
• W2080666971 creator A5065746163 @default.
• W2080666971 creator A5084919386 @default.
• W2080666971 date "2004-10-01" @default.
• W2080666971 modified "2023-10-18" @default.
• W2080666971 title "The effects of coadministration of dietary copper and zinc supplements on atherosclerosis, antioxidant enzymes and indices of lipid peroxidation in the cholesterol-fed rabbit" @default.
• W2080666971 cites W1536516181 @default.
• W2080666971 cites W1591568506 @default.
• W2080666971 cites W1775749144 @default.
• W2080666971 cites W1829110127 @default.
• W2080666971 cites W1881908646 @default.
• W2080666971 cites W1927102686 @default.
• W2080666971 cites W1971861437 @default.
• W2080666971 cites W1983310681 @default.
• W2080666971 cites W1993267618 @default.
• W2080666971 cites W1995751234 @default.
• W2080666971 cites W1997696176 @default.
• W2080666971 cites W1998344524 @default.
• W2080666971 cites W2007675570 @default.
• W2080666971 cites W2010190957 @default.
• W2080666971 cites W2012950039 @default.
• W2080666971 cites W2014918310 @default.
• W2080666971 cites W2015940077 @default.
• W2080666971 cites W2023691727 @default.
• W2080666971 cites W2024769251 @default.
• W2080666971 cites W2041977384 @default.
• W2080666971 cites W2060003134 @default.
• W2080666971 cites W2074156626 @default.
• W2080666971 cites W2078223151 @default.
• W2080666971 cites W2085720276 @default.
• W2080666971 cites W2086222728 @default.
• W2080666971 cites W2094929063 @default.
• W2080666971 cites W2098646953 @default.
• W2080666971 cites W2099892957 @default.
• W2080666971 cites W2120812572 @default.
• W2080666971 cites W2138457034 @default.
• W2080666971 cites W2142473051 @default.
• W2080666971 cites W2144207037 @default.
• W2080666971 cites W2162544533 @default.
• W2080666971 cites W228963871 @default.
• W2080666971 cites W2312045275 @default.
• W2080666971 cites W2413559324 @default.
• W2080666971 cites W2436101689 @default.
• W2080666971 cites W266439145 @default.
• W2080666971 cites W4241696236 @default.
• W2080666971 doi "https://doi.org/10.1111/j.0959-9673.2004.00392.x" @default.
• W2080666971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2517529" @default.
• W2080666971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15379959" @default.
• W2080666971 hasPublicationYear "2004" @default.
• W2080666971 type Work @default.
• W2080666971 sameAs 2080666971 @default.
• W2080666971 citedByCount "43" @default.
• W2080666971 countsByYear W20806669712012 @default.
• W2080666971 countsByYear W20806669712013 @default.
• W2080666971 countsByYear W20806669712014 @default.
• W2080666971 countsByYear W20806669712017 @default.
• W2080666971 countsByYear W20806669712019 @default.
• W2080666971 countsByYear W20806669712020 @default.
• W2080666971 countsByYear W20806669712021 @default.
• W2080666971 countsByYear W20806669712022 @default.
• W2080666971 countsByYear W20806669712023 @default.
• W2080666971 crossrefType "journal-article" @default.
• W2080666971 hasAuthorship W2080666971A5026005703 @default.
• W2080666971 hasAuthorship W2080666971A5038854437 @default.
• W2080666971 hasAuthorship W2080666971A5065746163 @default.
• W2080666971 hasAuthorship W2080666971A5084919386 @default.
• W2080666971 hasBestOaLocation W20806669712 @default.
• W2080666971 hasConcept C126322002 @default.
• W2080666971 hasConcept C134018914 @default.
• W2080666971 hasConcept C140793950 @default.
• W2080666971 hasConcept C178790620 @default.
• W2080666971 hasConcept C185592680 @default.
• W2080666971 hasConcept C2778004101 @default.
• W2080666971 hasConcept C2778163477 @default.
• W2080666971 hasConcept C2779980429 @default.
• W2080666971 hasConcept C2780829032 @default.
• W2080666971 hasConcept C28452662 @default.
• W2080666971 hasConcept C535196362 @default.
• W2080666971 hasConcept C544778455 @default.
• W2080666971 hasConcept C55493867 @default.
• W2080666971 hasConcept C62231903 @default.
• W2080666971 hasConcept C71924100 @default.
• W2080666971 hasConcept C86803240 @default.
• W2080666971 hasConceptScore W2080666971C126322002 @default.
• W2080666971 hasConceptScore W2080666971C134018914 @default.
• W2080666971 hasConceptScore W2080666971C140793950 @default.
• W2080666971 hasConceptScore W2080666971C178790620 @default.
• W2080666971 hasConceptScore W2080666971C185592680 @default.
• W2080666971 hasConceptScore W2080666971C2778004101 @default.
• W2080666971 hasConceptScore W2080666971C2778163477 @default.
• W2080666971 hasConceptScore W2080666971C2779980429 @default.
• W2080666971 hasConceptScore W2080666971C2780829032 @default.
• W2080666971 hasConceptScore W2080666971C28452662 @default.
• W2080666971 hasConceptScore W2080666971C535196362 @default.
• W2080666971 hasConceptScore W2080666971C544778455 @default.

• next