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• W2080667819 abstract "Background Celecoxib, a non‐steroidal anti‐inflammatory drug that selectively inhibits cyclooxygenase‐2 ( COX ‐2), has shown an important anticarcinogenic effect for the treatment of squamous cell carcinoma. The use of COX ‐2 inhibitors has effectively inhibited the growth of H ead and N eck S quamous C ell C arcinoma ( HNSCC ) cell lines, while a recent phase 1 trial demonstrated good response rate of cancer cells to this drug with minimal toxicity. Possible targets of celecoxib include proteins involved in cell proliferation and apoptosis control. Additionally, celecoxib antitumoral activity has been linked with a COX ‐2‐independent event. Methods To better understand which cellular mechanisms are targeted by celecoxib, its effects upon the A kt signaling pathway using two different HNSCC cell lines were analyzed through cell viability assay, immunofluorescence, and W estern blotting. Results The results showed decreased levels of C yclin D 1 and p A kt protein expression in vitro . The number of viable cells was also diminished after celecoxib treatment. Conclusion As A kt pathway seems to be a valuable target for the HNSCC therapy, the results presented herein confirm that celecoxib can be considered as an alternative adjuvant drug for HNSCC treatment." @default.
• W2080667819 created "2016-06-24" @default.
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• W2080667819 date "2013-05-16" @default.
• W2080667819 modified "2023-10-03" @default.
• W2080667819 title "Effects of celecoxib treatment over the AKT pathway in head and neck squamous cell carcinoma" @default.
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• W2080667819 doi "https://doi.org/10.1111/jop.12081" @default.
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