Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080668835> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2080668835 endingPage "131" @default.
- W2080668835 startingPage "131" @default.
- W2080668835 abstract "Experiments were carried out to evaluate the effect of nitric oxide exposure on the ability of NADPH-dependent microsomal electron transfer to mobilize iron from ferritin. Such interactions could play a role in potential antioxidant actions of nitric oxide (NO). Preincubation of the microsomes from phenobarbital-treated rats with NO donors such asS-nitroso-d,l-N-acetyl penicillamine (SNAP),S-nitroso-l-glutathione, SIN-1, and DETANONOate followed by centrifugation, washing, and resuspension of the microsomes resulted in a decrease in the ferritin-dependent oxidation of 2′,7′-dichlorofluorescein diacetate (DCFDA) or ferritin-catalyzed chemiluminescence compared to microsomes pretreated with buffer. The ferritin-stimulated rate of oxidation of DCFDA or of chemiluminescence was completely restored if the microsomal preincubation with NO donors was performed in the presence of hemoglobin. In contrast to results with ferritin, ferric-stimulated oxidation of the dye was not affected by any of the tested NO donors. The microsomal oxidation of aminopyrine was inhibited after SNAP treatment, indicating that NO inhibited cytochrome P450 catalyzed activity. Inhibition of cytochrome P450 also resulted in an inhibition of microsomal production of superoxide. Similar results were obtained using microsomes from a cloned cell line which express the CYP2E1 isoform. Since superoxide is required for the mobilization of iron from ferritin by microsomes, inhibition of superoxide production as a consequence of NO interaction with cytochrome P450 is likely to be responsible for the prevention of ferritin-catalyzed formation of reactive oxygen species by NO donors. The results suggest that NO could exhibit an antioxidant capacity through its ability of decreasing the activity of iron–heme compounds, such as cytochrome P450, preventing the release of catalytically active iron from ferritin, and thus decreasing the ability to generate oxygen free radicals involved in cytotoxicity." @default.
- W2080668835 created "2016-06-24" @default.
- W2080668835 creator A5003749623 @default.
- W2080668835 creator A5007013466 @default.
- W2080668835 creator A5008941841 @default.
- W2080668835 creator A5033231895 @default.
- W2080668835 creator A5038887844 @default.
- W2080668835 creator A5065428373 @default.
- W2080668835 creator A5081164979 @default.
- W2080668835 creator A5090665560 @default.
- W2080668835 date "2010-06-01" @default.
- W2080668835 modified "2023-09-26" @default.
- W2080668835 title "513 DNA copy number changes in radiation-induced mammary carcinoma of (SD × COP) F1 hybrid rats" @default.
- W2080668835 doi "https://doi.org/10.1016/s1359-6349(10)71314-8" @default.
- W2080668835 hasPublicationYear "2010" @default.
- W2080668835 type Work @default.
- W2080668835 sameAs 2080668835 @default.
- W2080668835 citedByCount "0" @default.
- W2080668835 crossrefType "journal-article" @default.
- W2080668835 hasAuthorship W2080668835A5003749623 @default.
- W2080668835 hasAuthorship W2080668835A5007013466 @default.
- W2080668835 hasAuthorship W2080668835A5008941841 @default.
- W2080668835 hasAuthorship W2080668835A5033231895 @default.
- W2080668835 hasAuthorship W2080668835A5038887844 @default.
- W2080668835 hasAuthorship W2080668835A5065428373 @default.
- W2080668835 hasAuthorship W2080668835A5081164979 @default.
- W2080668835 hasAuthorship W2080668835A5090665560 @default.
- W2080668835 hasConcept C178790620 @default.
- W2080668835 hasConcept C181199279 @default.
- W2080668835 hasConcept C185592680 @default.
- W2080668835 hasConcept C2778004101 @default.
- W2080668835 hasConcept C2778319317 @default.
- W2080668835 hasConcept C2779964046 @default.
- W2080668835 hasConcept C2780795997 @default.
- W2080668835 hasConcept C28859421 @default.
- W2080668835 hasConcept C29311851 @default.
- W2080668835 hasConcept C519581460 @default.
- W2080668835 hasConcept C538909803 @default.
- W2080668835 hasConcept C55493867 @default.
- W2080668835 hasConcept C87644729 @default.
- W2080668835 hasConceptScore W2080668835C178790620 @default.
- W2080668835 hasConceptScore W2080668835C181199279 @default.
- W2080668835 hasConceptScore W2080668835C185592680 @default.
- W2080668835 hasConceptScore W2080668835C2778004101 @default.
- W2080668835 hasConceptScore W2080668835C2778319317 @default.
- W2080668835 hasConceptScore W2080668835C2779964046 @default.
- W2080668835 hasConceptScore W2080668835C2780795997 @default.
- W2080668835 hasConceptScore W2080668835C28859421 @default.
- W2080668835 hasConceptScore W2080668835C29311851 @default.
- W2080668835 hasConceptScore W2080668835C519581460 @default.
- W2080668835 hasConceptScore W2080668835C538909803 @default.
- W2080668835 hasConceptScore W2080668835C55493867 @default.
- W2080668835 hasConceptScore W2080668835C87644729 @default.
- W2080668835 hasIssue "5" @default.
- W2080668835 hasLocation W20806688351 @default.
- W2080668835 hasOpenAccess W2080668835 @default.
- W2080668835 hasPrimaryLocation W20806688351 @default.
- W2080668835 hasRelatedWork W1697546316 @default.
- W2080668835 hasRelatedWork W178190488 @default.
- W2080668835 hasRelatedWork W2002021104 @default.
- W2080668835 hasRelatedWork W2019411611 @default.
- W2080668835 hasRelatedWork W2025906826 @default.
- W2080668835 hasRelatedWork W2090992535 @default.
- W2080668835 hasRelatedWork W2142579967 @default.
- W2080668835 hasRelatedWork W2146874165 @default.
- W2080668835 hasRelatedWork W276645295 @default.
- W2080668835 hasRelatedWork W2984807564 @default.
- W2080668835 hasVolume "8" @default.
- W2080668835 isParatext "false" @default.
- W2080668835 isRetracted "false" @default.
- W2080668835 magId "2080668835" @default.
- W2080668835 workType "article" @default.