FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080672743> ?p ?o ?g. }

• W2080672743 endingPage "576" @default.
• W2080672743 startingPage "567" @default.
• W2080672743 abstract "Summary. Background: The integrin αIIbβ3 is the major mediator of platelet aggregation and has, therefore, become an important target of antithrombotic therapy. Antagonists of αIIbβ3, for example abciximab, tirofiban and eptifibatide, are used in the treatment of acute coronary syndromes. However, in addition to effective blockade of the integrin, binding of can induce conformational changes in the integrin and can also induce integrin clustering. This class effect of RGD-ligand mimetics might, therefore, underlie paradoxical platelet activation and thrombosis previously reported. Objectives: To examine the components of signaling pathways and functional responses in platelets that may underlie this phenomenon of paradoxical platelet activation. Methods: We assessed the effect of lotrafiban, and other αIIbβ3 antagonists including the clinically used drug tirofiban, on tyrosine phosphorylation of key signaling proteins in platelets by immunoblotting and also platelet functional outputs such as cytosolic calcium responses, phosphatidylserine exposure (pro-coagulant activity) and dense granule release. Results: In all cases, no effect of αIIbβ3 antagonists were observed on their own, but these integrin antagonists did lead to a marked potentiation of glycoprotein VI (GPVI)-associated FcR γ-chain phosphorylation, activation of Src family kinases and Syk kinase. This correlated with increased dense granule secretion, cytosolic calcium response and exposure of phosphatidylserine on the platelet surface. P2Y12 antagonism abolished the potentiated phosphatidylserine exposure and dense granule secretion but not the cytosolic calcium response. Conclusions: These data provide a mechanism for enhancement of platelet activity by αIIbβ3 inhibitors, but also reveal a potentially important signaling pathway operating from the integrin to GPVI signaling." @default.
• W2080672743 created "2016-06-24" @default.
• W2080672743 creator A5035254895 @default.
• W2080672743 creator A5036288401 @default.
• W2080672743 creator A5051674131 @default.
• W2080672743 creator A5070122745 @default.
• W2080672743 creator A5076444425 @default.
• W2080672743 date "2010-03-01" @default.
• W2080672743 modified "2023-09-26" @default.
• W2080672743 title "RGD‐ligand mimetic antagonists of integrin αIIbβ3 paradoxically enhance GPVI‐induced human platelet activation" @default.
• W2080672743 cites W1513381909 @default.
• W2080672743 cites W1543980776 @default.
• W2080672743 cites W1570510735 @default.
• W2080672743 cites W1925295096 @default.
• W2080672743 cites W1966007510 @default.
• W2080672743 cites W1967664376 @default.
• W2080672743 cites W1968260614 @default.
• W2080672743 cites W1989381306 @default.
• W2080672743 cites W1993859463 @default.
• W2080672743 cites W1995553619 @default.
• W2080672743 cites W2003506380 @default.
• W2080672743 cites W2005937826 @default.
• W2080672743 cites W2007046037 @default.
• W2080672743 cites W2017021371 @default.
• W2080672743 cites W2020249770 @default.
• W2080672743 cites W2025510606 @default.
• W2080672743 cites W2027695939 @default.
• W2080672743 cites W2038552179 @default.
• W2080672743 cites W2040335095 @default.
• W2080672743 cites W2043823402 @default.
• W2080672743 cites W2046737719 @default.
• W2080672743 cites W2051185006 @default.
• W2080672743 cites W2071077438 @default.
• W2080672743 cites W2075363343 @default.
• W2080672743 cites W2077621403 @default.
• W2080672743 cites W2088007882 @default.
• W2080672743 cites W2091326509 @default.
• W2080672743 cites W2099745384 @default.
• W2080672743 cites W2100273384 @default.
• W2080672743 cites W2103746902 @default.
• W2080672743 cites W2111066965 @default.
• W2080672743 cites W2119636762 @default.
• W2080672743 cites W2133478831 @default.
• W2080672743 cites W2141288132 @default.
• W2080672743 cites W2154909249 @default.
• W2080672743 cites W2156901367 @default.
• W2080672743 cites W2167248515 @default.
• W2080672743 cites W4239282106 @default.
• W2080672743 cites W4239907137 @default.
• W2080672743 doi "https://doi.org/10.1111/j.1538-7836.2009.03719.x" @default.
• W2080672743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20002543" @default.
• W2080672743 hasPublicationYear "2010" @default.
• W2080672743 type Work @default.
• W2080672743 sameAs 2080672743 @default.
• W2080672743 citedByCount "19" @default.
• W2080672743 countsByYear W20806727432012 @default.
• W2080672743 countsByYear W20806727432013 @default.
• W2080672743 countsByYear W20806727432014 @default.
• W2080672743 countsByYear W20806727432019 @default.
• W2080672743 countsByYear W20806727432020 @default.
• W2080672743 countsByYear W20806727432021 @default.
• W2080672743 countsByYear W20806727432023 @default.
• W2080672743 crossrefType "journal-article" @default.
• W2080672743 hasAuthorship W2080672743A5035254895 @default.
• W2080672743 hasAuthorship W2080672743A5036288401 @default.
• W2080672743 hasAuthorship W2080672743A5051674131 @default.
• W2080672743 hasAuthorship W2080672743A5070122745 @default.
• W2080672743 hasAuthorship W2080672743A5076444425 @default.
• W2080672743 hasBestOaLocation W20806727431 @default.
• W2080672743 hasConcept C119524353 @default.
• W2080672743 hasConcept C11960822 @default.
• W2080672743 hasConcept C126322002 @default.
• W2080672743 hasConcept C170493617 @default.
• W2080672743 hasConcept C185592680 @default.
• W2080672743 hasConcept C195687474 @default.
• W2080672743 hasConcept C203014093 @default.
• W2080672743 hasConcept C2776335557 @default.
• W2080672743 hasConcept C2777553839 @default.
• W2080672743 hasConcept C2777871224 @default.
• W2080672743 hasConcept C2778918659 @default.
• W2080672743 hasConcept C2779637612 @default.
• W2080672743 hasConcept C2780400711 @default.
• W2080672743 hasConcept C2780573682 @default.
• W2080672743 hasConcept C2910542480 @default.
• W2080672743 hasConcept C3018697912 @default.
• W2080672743 hasConcept C41625074 @default.
• W2080672743 hasConcept C45393284 @default.
• W2080672743 hasConcept C500558357 @default.
• W2080672743 hasConcept C55493867 @default.
• W2080672743 hasConcept C71924100 @default.
• W2080672743 hasConcept C86803240 @default.
• W2080672743 hasConcept C89560881 @default.
• W2080672743 hasConcept C95444343 @default.
• W2080672743 hasConcept C98274493 @default.
• W2080672743 hasConceptScore W2080672743C119524353 @default.
• W2080672743 hasConceptScore W2080672743C11960822 @default.
• W2080672743 hasConceptScore W2080672743C126322002 @default.
• W2080672743 hasConceptScore W2080672743C170493617 @default.

• next