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- W2080676603 abstract "The presence ofl-arginine methylester (AME),l-arginine ethylester (AEE), orN-nitro-l-arginine methylester (NAME) in the growth media ofStaphylococcus aureusincreased the nitric oxide synthase (NOS) activity approximately 5- to 14-fold. The increase of NOS activity was confirmed by two assay methods, namely assaying the formation of L-[3H] citrulline from L-[3H] arginine and NO formation. The increase of NOS activity was most likely due to increasedde novosynthesis, demonstrated by Western immunoblot analysis. The addition of methanol to the culture medium also increased the NOS activity as much as that found with the above three compounds. Evidence is presented to show that AME, AEE, or NAME gave rise to the formation of methanolin vivoby the action of intracellular esterase(s) and that methanol is subsequently involved in the induction of NOS in this bacterial system." @default.
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- W2080676603 date "1998-05-01" @default.
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- W2080676603 title "Methylesters ofl-Arginine andN-Nitro-l-arginine Induce Nitric Oxide Synthase inStaphylococcus aureus" @default.
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- W2080676603 doi "https://doi.org/10.1006/bbrc.1998.8638" @default.
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