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• W2080677166 abstract "Chromosomes isolated from mouse leukemia L1210 cells were taken up by mouse macrophages, HeLa cells, and rat embryo fibroblasts following simple exposure in vitro. The process, which resembles pinocytosis or phagocytosis, was traced by autoradiography of chromosomes prelabeled with thymidine-H(3), and by staining techniques and phase contrast microscopy. During the first six hours, the uptake of chromosomes was restricted to the cytoplasm, but there was some evidence of penetration into the nucleus after 16 and 26 hours of exposure. Treatment of rat fibroblasts with glucose and insulin markedly enhanced the uptake of chromosomes, whereas iodoacetate inhibited their penetration." @default.
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• W2080677166 date "1963-10-01" @default.
• W2080677166 modified "2023-09-26" @default.
• W2080677166 title "UPTAKE OF MAMMALIAN CHROMOSOMES BY MAMMALIAN CELLS" @default.
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• W2080677166 doi "https://doi.org/10.1083/jcb.19.1.71" @default.
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