FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080679924> ?p ?o ?g. }

• W2080679924 endingPage "206" @default.
• W2080679924 startingPage "200" @default.
• W2080679924 abstract "Ghrelin is an orexigenic hormone produced mainly by the gastrointestinal system and the brain. Much evidence also indicates a role for ghrelin in sleep and thermoregulation. Further, ghrelin was recently implicated in immune system modulation. Administration of bacterial lipopolysaccharide (LPS) induces fever, anorexia, and increased non-rapid-eye movement sleep (NREMS) and these actions are mediated primarily by proinflammatory cytokines. Ghrelin reduces LPS-induced fever, suppresses circulating levels of proinflammatory cytokines and reduces the severity and mortality of various models of experimental endotoxemia. In the present study, we determined the role of intact ghrelin signaling in LPS-induced sleep, feeding, and thermoregulatory responses in mice. Sleep-wake activity was determined after intraperitoneal, dark onset administration of 0.4, 2 and 10 μg LPS in preproghrelin knockout (KO) and wild-type (WT) mice. In addition, body temperature, motor activity and changes in 24-h food intake and body weight were measured. LPS induced dose-dependent increases in NREMS, and suppressed rapid-eye movement sleep, electroencephalographic slow-wave activity, motor activity, food intake and body weight in both Ppg KO and WT mice. Body temperature changes showed a biphasic pattern with a decrease during the dark period followed by an increase in the light phase. The effects of the low and middle doses of LPS were indistinguishable between the two genotypes. Administration of 10 μg LPS, however, induced significantly larger changes in NREMS and wakefulness amounts, body temperature, food intake and body weight in the Ppg KO mice. These findings support a role for ghrelin as an endogenous modulator of inflammatory responses and a central component of arousal and feeding circuits." @default.
• W2080679924 created "2016-06-24" @default.
• W2080679924 creator A5012696927 @default.
• W2080679924 creator A5037968675 @default.
• W2080679924 date "2014-02-01" @default.
• W2080679924 modified "2023-10-06" @default.
• W2080679924 title "Sickness behaviour after lipopolysaccharide treatment in ghrelin deficient mice" @default.
• W2080679924 cites W1485313316 @default.
• W2080679924 cites W1568345323 @default.
• W2080679924 cites W1757080849 @default.
• W2080679924 cites W1880976932 @default.
• W2080679924 cites W1965589496 @default.
• W2080679924 cites W1969773497 @default.
• W2080679924 cites W1977252409 @default.
• W2080679924 cites W1981296195 @default.
• W2080679924 cites W1985867627 @default.
• W2080679924 cites W1994715351 @default.
• W2080679924 cites W1999244000 @default.
• W2080679924 cites W2000624093 @default.
• W2080679924 cites W2004469691 @default.
• W2080679924 cites W2005076729 @default.
• W2080679924 cites W2007246387 @default.
• W2080679924 cites W2012968633 @default.
• W2080679924 cites W2020131327 @default.
• W2080679924 cites W2020836115 @default.
• W2080679924 cites W2036820891 @default.
• W2080679924 cites W2045983302 @default.
• W2080679924 cites W2076953990 @default.
• W2080679924 cites W2097265990 @default.
• W2080679924 cites W2098059948 @default.
• W2080679924 cites W2109572497 @default.
• W2080679924 cites W2116753388 @default.
• W2080679924 cites W2121806582 @default.
• W2080679924 cites W2135340140 @default.
• W2080679924 cites W2136609029 @default.
• W2080679924 cites W2146379644 @default.
• W2080679924 cites W2221316846 @default.
• W2080679924 cites W2287771815 @default.
• W2080679924 cites W4235460794 @default.
• W2080679924 doi "https://doi.org/10.1016/j.bbi.2013.11.017" @default.
• W2080679924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3951816" @default.
• W2080679924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24309634" @default.
• W2080679924 hasPublicationYear "2014" @default.
• W2080679924 type Work @default.
• W2080679924 sameAs 2080679924 @default.
• W2080679924 citedByCount "21" @default.
• W2080679924 countsByYear W20806799242014 @default.
• W2080679924 countsByYear W20806799242015 @default.
• W2080679924 countsByYear W20806799242016 @default.
• W2080679924 countsByYear W20806799242017 @default.
• W2080679924 countsByYear W20806799242018 @default.
• W2080679924 countsByYear W20806799242019 @default.
• W2080679924 countsByYear W20806799242020 @default.
• W2080679924 countsByYear W20806799242021 @default.
• W2080679924 countsByYear W20806799242022 @default.
• W2080679924 countsByYear W20806799242023 @default.
• W2080679924 crossrefType "journal-article" @default.
• W2080679924 hasAuthorship W2080679924A5012696927 @default.
• W2080679924 hasAuthorship W2080679924A5037968675 @default.
• W2080679924 hasBestOaLocation W20806799242 @default.
• W2080679924 hasConcept C100564792 @default.
• W2080679924 hasConcept C118303440 @default.
• W2080679924 hasConcept C118552586 @default.
• W2080679924 hasConcept C126322002 @default.
• W2080679924 hasConcept C134018914 @default.
• W2080679924 hasConcept C138906646 @default.
• W2080679924 hasConcept C164027704 @default.
• W2080679924 hasConcept C170493617 @default.
• W2080679924 hasConcept C2776914184 @default.
• W2080679924 hasConcept C2777003273 @default.
• W2080679924 hasConcept C2777205416 @default.
• W2080679924 hasConcept C2778654693 @default.
• W2080679924 hasConcept C2778754761 @default.
• W2080679924 hasConcept C2779320081 @default.
• W2080679924 hasConcept C2779357093 @default.
• W2080679924 hasConcept C522805319 @default.
• W2080679924 hasConcept C71315377 @default.
• W2080679924 hasConcept C71924100 @default.
• W2080679924 hasConcept C93984277 @default.
• W2080679924 hasConceptScore W2080679924C100564792 @default.
• W2080679924 hasConceptScore W2080679924C118303440 @default.
• W2080679924 hasConceptScore W2080679924C118552586 @default.
• W2080679924 hasConceptScore W2080679924C126322002 @default.
• W2080679924 hasConceptScore W2080679924C134018914 @default.
• W2080679924 hasConceptScore W2080679924C138906646 @default.
• W2080679924 hasConceptScore W2080679924C164027704 @default.
• W2080679924 hasConceptScore W2080679924C170493617 @default.
• W2080679924 hasConceptScore W2080679924C2776914184 @default.
• W2080679924 hasConceptScore W2080679924C2777003273 @default.
• W2080679924 hasConceptScore W2080679924C2777205416 @default.
• W2080679924 hasConceptScore W2080679924C2778654693 @default.
• W2080679924 hasConceptScore W2080679924C2778754761 @default.
• W2080679924 hasConceptScore W2080679924C2779320081 @default.
• W2080679924 hasConceptScore W2080679924C2779357093 @default.
• W2080679924 hasConceptScore W2080679924C522805319 @default.
• W2080679924 hasConceptScore W2080679924C71315377 @default.
• W2080679924 hasConceptScore W2080679924C71924100 @default.
• W2080679924 hasConceptScore W2080679924C93984277 @default.

• next