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• W2080681608 endingPage "2159" @default.
• W2080681608 startingPage "2147" @default.
• W2080681608 abstract "Aims: Studies have reported that redox signaling in the hypothalamus participates in nutrient sensing. The current study aimed to determine if the activation of reactive oxygen species-related enzymes (ROS-RE) in the hypothalamus participates in regulating neuropeptide Y (NPY)-mediated eating. Moreover, possible roles of proopiomelanocortin (POMC) and atypical protein kinase C (aPKC) were also investigated. Rats were treated daily with phenylpropanolamine (PPA) for 4 days. Changes in the expression levels of ROS-RE, POMC, NPY, and aPKC were assessed and compared. Results: Results showed that ROS-RE, POMC, and aPKC increased, with a maximal response on Day 2 (anorectic effect) and with a restoration to the normal level on Day 4 (tolerant effect). By contrast, NPY expression decreased, and the expression pattern of NPY proved opposite those of ROS-RE and POMC. Central inhibition of ROS production by ICV infusion of ROS scavenger attenuated PPA anorexia, revealing a crucial role of ROS in regulating eating. Cerebral aPKC knockdown by ICV infusion of antisense aPKC modulated the expression of ROS-RE, POMC, and NPY. Conclusion: Results suggest that ROS-RE/POMC- and NPY-containing neurons function reciprocally in regulating both the anorectic and tolerant effects of PPA, while aPKC is upstream of these regulators. Innovation: These results may further the understanding of ROS-RE and aPKC in the control of PPA anorexia. Antioxid. Redox Signal. 15, 2147–2159." @default.
• W2080681608 created "2016-06-24" @default.
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• W2080681608 date "2011-10-15" @default.
• W2080681608 modified "2023-09-26" @default.
• W2080681608 title "Role of Reactive Oxygen Species-Related Enzymes in Neuropeptide Y and Proopiomelanocortin-Mediated Appetite Control: A Study Using Atypical Protein Kinase C Knockdown" @default.
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• W2080681608 doi "https://doi.org/10.1089/ars.2010.3738" @default.
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