FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080683775> ?p ?o ?g. }

• W2080683775 abstract "The characterization of molecular changes in diseased tissues gives insight into pathophysiological mechanisms and is important for the therapeutic development. Genome-wide gene expression analysis has proven valuable for identifying biological processes in neurodegenerative diseases using post mortem human brain tissue and numerous datasets are publically available. However, many studies utilize heterogeneous tissue samples consisting of multiple cell types, all of which contribute to global gene expression values, confounding biological interpretation of the data. In particular, changes in numbers of neuronal and glial cells occurring in neurodegeneration confound transcriptomic analyses, particularly in human brain tissues where sample availability and control is limited. To identify cell specific gene expression changes in neurodegenerative disease, we have applied our recently published computational deconvolution method, population specific expression analysis (PSEA). PSEA estimates cell-type-specific expression values using reference expression measures, which in the case of brain tissue comprises mRNAs with cell-type-specific expression in neurons, astrocytes, oligodendrocytes and microglia. As an exercise in PSEA implementation and hypothesis development regarding neurodegenerative diseases, we applied PSEA to Parkinson’s and Huntington’s disease (PD, HD) datasets. Genes identified as differentially expressed in substantia nigra pars compacta neurons by PSEA were validated using external laser capture microdissection data. Network analysis and Annotation Clustering (DAVID) identified molecular processes implicated by differential gene expression in specific cell types. The results of these analyses provided new insights into the implementation of PSEA in brain tissues and additional refinement of molecular signatures in human HD and PD." @default.
• W2080683775 created "2016-06-24" @default.
• W2080683775 creator A5009228627 @default.
• W2080683775 creator A5012093503 @default.
• W2080683775 creator A5053165887 @default.
• W2080683775 creator A5071837576 @default.
• W2080683775 creator A5082016176 @default.
• W2080683775 date "2015-01-09" @default.
• W2080683775 modified "2023-09-25" @default.
• W2080683775 title "Computational deconvolution of genome wide expression data from Parkinson's and Huntington's disease brain tissues using population-specific expression analysis" @default.
• W2080683775 cites W1488067222 @default.
• W2080683775 cites W1508843172 @default.
• W2080683775 cites W1546952499 @default.
• W2080683775 cites W1556109721 @default.
• W2080683775 cites W1965942744 @default.
• W2080683775 cites W1968189171 @default.
• W2080683775 cites W1973083723 @default.
• W2080683775 cites W1973962743 @default.
• W2080683775 cites W1974250048 @default.
• W2080683775 cites W1974434733 @default.
• W2080683775 cites W1976244966 @default.
• W2080683775 cites W1979881437 @default.
• W2080683775 cites W1981144487 @default.
• W2080683775 cites W1981215030 @default.
• W2080683775 cites W1982557547 @default.
• W2080683775 cites W1990677550 @default.
• W2080683775 cites W1991979830 @default.
• W2080683775 cites W1993098682 @default.
• W2080683775 cites W1993978594 @default.
• W2080683775 cites W1994698160 @default.
• W2080683775 cites W1999639946 @default.
• W2080683775 cites W2004349171 @default.
• W2080683775 cites W2004354005 @default.
• W2080683775 cites W2009170866 @default.
• W2080683775 cites W2014699342 @default.
• W2080683775 cites W2024234404 @default.
• W2080683775 cites W2044162798 @default.
• W2080683775 cites W2044434127 @default.
• W2080683775 cites W2060588252 @default.
• W2080683775 cites W2063069972 @default.
• W2080683775 cites W2069157974 @default.
• W2080683775 cites W2069788298 @default.
• W2080683775 cites W2069799575 @default.
• W2080683775 cites W2073567531 @default.
• W2080683775 cites W2074900534 @default.
• W2080683775 cites W2080995987 @default.
• W2080683775 cites W2093358653 @default.
• W2080683775 cites W2106357844 @default.
• W2080683775 cites W2114413959 @default.
• W2080683775 cites W2115155255 @default.
• W2080683775 cites W2116634113 @default.
• W2080683775 cites W2117499730 @default.
• W2080683775 cites W2118258530 @default.
• W2080683775 cites W2119375793 @default.
• W2080683775 cites W2121642311 @default.
• W2080683775 cites W2121926054 @default.
• W2080683775 cites W2123329045 @default.
• W2080683775 cites W2124940469 @default.
• W2080683775 cites W2130187979 @default.
• W2080683775 cites W2137992270 @default.
• W2080683775 cites W2139233019 @default.
• W2080683775 cites W2142635246 @default.
• W2080683775 cites W2143950810 @default.
• W2080683775 cites W2144457054 @default.
• W2080683775 cites W2155015733 @default.
• W2080683775 cites W2155142785 @default.
• W2080683775 cites W2156104877 @default.
• W2080683775 cites W2156179625 @default.
• W2080683775 cites W2158217645 @default.
• W2080683775 cites W2158240093 @default.
• W2080683775 cites W2160697532 @default.
• W2080683775 cites W2160748841 @default.
• W2080683775 cites W2160854976 @default.
• W2080683775 cites W2163485494 @default.
• W2080683775 cites W2164738639 @default.
• W2080683775 cites W2169216199 @default.
• W2080683775 cites W2323361337 @default.
• W2080683775 cites W2333389992 @default.
• W2080683775 cites W2418351874 @default.
• W2080683775 cites W2506243051 @default.
• W2080683775 cites W62603772 @default.
• W2080683775 doi "https://doi.org/10.3389/fnins.2014.00441" @default.
• W2080683775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4288238" @default.
• W2080683775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25620908" @default.
• W2080683775 hasPublicationYear "2015" @default.
• W2080683775 type Work @default.
• W2080683775 sameAs 2080683775 @default.
• W2080683775 citedByCount "22" @default.
• W2080683775 countsByYear W20806837752015 @default.
• W2080683775 countsByYear W20806837752016 @default.
• W2080683775 countsByYear W20806837752017 @default.
• W2080683775 countsByYear W20806837752018 @default.
• W2080683775 countsByYear W20806837752020 @default.
• W2080683775 countsByYear W20806837752021 @default.
• W2080683775 countsByYear W20806837752022 @default.
• W2080683775 countsByYear W20806837752023 @default.
• W2080683775 crossrefType "journal-article" @default.
• W2080683775 hasAuthorship W2080683775A5009228627 @default.
• W2080683775 hasAuthorship W2080683775A5012093503 @default.
• W2080683775 hasAuthorship W2080683775A5053165887 @default.

• next