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• W2080684014 abstract "Objective: To investigate whether recombinant erythropoietin (rhEPO) reduces the need for transfusion in extremely low birth weight (ELBW) infants (birth weight 500-999 g) and to determine the optimal time for treatment. Methods: In a blinded multicenter trial, 219 ELBW infants were randomized on day 3 to one of 3 groups: early rhEPO group (rhEPO from the first week for 9 weeks, n = 74), late rhEPO group (rhEPO from the fourth week for 6 weeks, n = 74), or control group (no rhEPO, n = 71). All infants received enteral iron (3-9 mg/kg/day) from the first week. The rhEPO β dose was 750 IU/kg/week. Success was defined as no transfusion and hematocrit levels never below 30%. Results: Success rate was 13% in the early rhEPO group, 11% in the late rhEPO group, and 4% in the control group (P =.026 for early rhEPO versus control group). Median transfusion volume was 0.4 versus 0.5 versus 0.7 mL/kg/day (P =.02) and median donor exposure was 1.0 versus 1.0 versus 2.0 (P =.05) in the early rhEPO group, the late rhEPO group, and the control group, respectively. Infection risk was not increased and weight gain was not delayed with rhEPO β. Conclusion: Early rhEPO β treatment effectively reduces the need for transfusion in ELBW infants. (J Pediatr 2002;141:8-15)" @default.
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• W2080684014 date "2002-07-01" @default.
• W2080684014 modified "2023-10-16" @default.
• W2080684014 title "Early treatment with erythropoietin β ameliorates anemia and reduces transfusion requirements in infants with birth weights below 1000 g" @default.
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• W2080684014 doi "https://doi.org/10.1067/mpd.2002.124309" @default.
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