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- W2080684315 abstract "Abstract The genetic changes of cyclin A , Dl , E and CDK2 were examined in human colorectal carcinomas by Southern‐blot analysis. Gene amplification of cyclin E was detected in 5 of 53 (9.4%) primary colorectal carcinoma tissues. Interestingly, in 3 of 5 tumors showing cyclin E gene amplification, the CDK2 gene was amplified simultaneously with rearrangements. No obvious correlation was detected between gene amplification and clinico‐pathological features of colorectal carcinomas. Out of 7 colon carcinoma cell lines, 2 showed gene amplification of cyclin E without gene amplification of CDK2. No amplification of cyclin A or Dl gene was found in any of the colorectal carcinoma tissues or colon carcinoma cell lines. Our results suggest that the concurrent amplification of cyclin E and CDK2 genes may play a role in colorectal carcinogenesis. © 1995 Wiley‐Liss Inc." @default.
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- W2080684315 date "1995-07-04" @default.
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- W2080684315 title "Concurrent amplification of cyclin E and CDK2 genes in colorectal carcinomas" @default.
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- W2080684315 doi "https://doi.org/10.1002/ijc.2910620107" @default.
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