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- W2080687603 abstract "In order to further assess lipid-carbohydrate interactions in familial hyperlipoproteinemia, the acute and chronic effects of glucagon (3 mg i.m.) on plasma total cholesterol, triglycerides, nonesterified fatty acids, and glucose were studied in 24 hospitalized patients with primary hyperlipoproteinemia. A single dose of glucagon significantly lowered plasma triglycerides over a period of 4 hr in types IIa, IIb, and V, but did not produce any significant change in plasma cholesterol in all types of hyperlipoproteinemia. As compared with a control period (5 days), glucagon fiven daily over 10 days lowered plasma total cholesterol significantly in types III, V, IIa, and IIb, but did not either in II homozygous or in IV. Glucagon lowered plasma triglycerides significantly in types III and V but produced only a transient fall followed by a progressive rise in type IIa, IIb, and IV. In all subjects studied, a positive correlation was found between the increase in plasma glucose at 120 min after a single dose of glucagon and the decrease of plasma triglycerides during chronic administration of glucagon (r = 0.451, p < 0.05). The effect of glucagon on plasma lipids was discussed." @default.
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- W2080687603 title "Effects of glucagon on plasma lipids in different types of primary hyperlipoproteinemia" @default.
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- W2080687603 doi "https://doi.org/10.1016/0026-0495(74)90061-4" @default.
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