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- W2080690912 endingPage "1013" @default.
- W2080690912 startingPage "1003" @default.
- W2080690912 abstract "The diagnosis of nodal marginal zone lymphoma is one of the remaining problem areas in hematopathology. Because no established positive markers exist for this lymphoma, it is frequently a diagnosis of exclusion, making distinction from other low-grade B-cell lymphomas difficult or even impossible. This systematic review summarizes and discusses the current knowledge on nodal marginal zone lymphoma, including clinical features, epidemiology and etiology, histology, and cytogenetic and molecular features. In particular, recent advances in diagnostics and pathogenesis are discussed. New immunohistochemical markers have become available that could be used as positive markers for nodal marginal zone lymphoma. These markers could be used to ensure more homogeneous study groups in future research. Also, recent gene expression studies and studies describing specific gene mutations have provided clues to the pathogenesis of nodal marginal zone lymphoma, suggesting deregulation of the nuclear factor kappa B pathway. Nevertheless, nodal marginal zone lymphoma remains an enigmatic entity, requiring further study to define its pathogenesis to allow an accurate diagnosis and tailored treatment. However, recent data indicate that it is not related to splenic or extranodal lymphoma, and that it is also not related to lymphoplasmacytic lymphoma. Thus, even though the diagnosis is not always easy, it is clearly a separate entity." @default.
- W2080690912 created "2016-06-24" @default.
- W2080690912 creator A5025624708 @default.
- W2080690912 creator A5031480761 @default.
- W2080690912 date "2013-06-30" @default.
- W2080690912 modified "2023-09-30" @default.
- W2080690912 title "Recognizing nodal marginal zone lymphoma: recent advances and pitfalls. A systematic review" @default.
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