Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080691054> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2080691054 endingPage "1491" @default.
- W2080691054 startingPage "1491" @default.
- W2080691054 abstract "We investigated the transport of levodopa from blood to brain in control and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) parkinsonian monkeys by using intracerebral microdialysis. The degree of parkinsonism was established by the monkey's clinical score and its postmortem striatali dopamine level. We administered levodopa plus carbidopa either orally or by intravenous injection. We estimated the blood-to-brain transport of levodopa as the ratio of its concentration in the brain's extracellular fluid to that in arterial plasma. This ratio was reduced in the MPTP parkinsonian monkeys, and we found an inverse relationship between the monkeys' ability to transport levodopa from blood to brain and their degree of parkinsonism. The oral administration of a high-protein meal or the intravenous infusion of large neutral amino acids before the administration of the levodopa plus carbidopa reduced the transport of levodopa into the brain, as measured by microdialysate collected from the striatum. We found that in two animals an intraperitoneal injection of the β-adrenergic agonist isoproterenol increased the blood-to-brain transport of levodopa. Pharmacologic manipulation of the transport of levodopa from blood to brain may offer a new strategy for the treatment of Parkinson's disease." @default.
- W2080691054 created "2016-06-24" @default.
- W2080691054 creator A5010730267 @default.
- W2080691054 creator A5014732616 @default.
- W2080691054 creator A5026655418 @default.
- W2080691054 creator A5035591752 @default.
- W2080691054 date "1994-08-01" @default.
- W2080691054 modified "2023-09-27" @default.
- W2080691054 title "Effect of plasma levels of large neutral amino acids and degree of parkinsonism on the blood‐to‐brain transport of levodopa in naive and MPTP parkinsonian monkeys" @default.
- W2080691054 doi "https://doi.org/10.1212/wnl.44.8.1491" @default.
- W2080691054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8058155" @default.
- W2080691054 hasPublicationYear "1994" @default.
- W2080691054 type Work @default.
- W2080691054 sameAs 2080691054 @default.
- W2080691054 citedByCount "43" @default.
- W2080691054 countsByYear W20806910542012 @default.
- W2080691054 countsByYear W20806910542013 @default.
- W2080691054 countsByYear W20806910542014 @default.
- W2080691054 countsByYear W20806910542016 @default.
- W2080691054 countsByYear W20806910542018 @default.
- W2080691054 countsByYear W20806910542019 @default.
- W2080691054 countsByYear W20806910542020 @default.
- W2080691054 countsByYear W20806910542021 @default.
- W2080691054 countsByYear W20806910542022 @default.
- W2080691054 countsByYear W20806910542023 @default.
- W2080691054 crossrefType "journal-article" @default.
- W2080691054 hasAuthorship W2080691054A5010730267 @default.
- W2080691054 hasAuthorship W2080691054A5014732616 @default.
- W2080691054 hasAuthorship W2080691054A5026655418 @default.
- W2080691054 hasAuthorship W2080691054A5035591752 @default.
- W2080691054 hasConcept C126322002 @default.
- W2080691054 hasConcept C137183658 @default.
- W2080691054 hasConcept C185592680 @default.
- W2080691054 hasConcept C2776525014 @default.
- W2080691054 hasConcept C2776754145 @default.
- W2080691054 hasConcept C2778674702 @default.
- W2080691054 hasConcept C2779134260 @default.
- W2080691054 hasConcept C2779734285 @default.
- W2080691054 hasConcept C2780304432 @default.
- W2080691054 hasConcept C2780405171 @default.
- W2080691054 hasConcept C42219234 @default.
- W2080691054 hasConcept C50156730 @default.
- W2080691054 hasConcept C513476851 @default.
- W2080691054 hasConcept C71924100 @default.
- W2080691054 hasConcept C98274493 @default.
- W2080691054 hasConceptScore W2080691054C126322002 @default.
- W2080691054 hasConceptScore W2080691054C137183658 @default.
- W2080691054 hasConceptScore W2080691054C185592680 @default.
- W2080691054 hasConceptScore W2080691054C2776525014 @default.
- W2080691054 hasConceptScore W2080691054C2776754145 @default.
- W2080691054 hasConceptScore W2080691054C2778674702 @default.
- W2080691054 hasConceptScore W2080691054C2779134260 @default.
- W2080691054 hasConceptScore W2080691054C2779734285 @default.
- W2080691054 hasConceptScore W2080691054C2780304432 @default.
- W2080691054 hasConceptScore W2080691054C2780405171 @default.
- W2080691054 hasConceptScore W2080691054C42219234 @default.
- W2080691054 hasConceptScore W2080691054C50156730 @default.
- W2080691054 hasConceptScore W2080691054C513476851 @default.
- W2080691054 hasConceptScore W2080691054C71924100 @default.
- W2080691054 hasConceptScore W2080691054C98274493 @default.
- W2080691054 hasIssue "8" @default.
- W2080691054 hasLocation W20806910541 @default.
- W2080691054 hasLocation W20806910542 @default.
- W2080691054 hasOpenAccess W2080691054 @default.
- W2080691054 hasPrimaryLocation W20806910541 @default.
- W2080691054 hasRelatedWork W137083958 @default.
- W2080691054 hasRelatedWork W1900332198 @default.
- W2080691054 hasRelatedWork W2002452414 @default.
- W2080691054 hasRelatedWork W2161985445 @default.
- W2080691054 hasRelatedWork W2162639939 @default.
- W2080691054 hasRelatedWork W2405564459 @default.
- W2080691054 hasRelatedWork W2461775076 @default.
- W2080691054 hasRelatedWork W2982184566 @default.
- W2080691054 hasRelatedWork W2995977730 @default.
- W2080691054 hasRelatedWork W3206641508 @default.
- W2080691054 hasVolume "44" @default.
- W2080691054 isParatext "false" @default.
- W2080691054 isRetracted "false" @default.
- W2080691054 magId "2080691054" @default.
- W2080691054 workType "article" @default.