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- W2080694825 endingPage "12" @default.
- W2080694825 startingPage "3" @default.
- W2080694825 abstract "Increasing cellular damage during the aging process is considered to be one factor limiting the lifespan of organisms. Besides the DNA and lipids, proteins are frequent targets of non-enzymatic modifications by reactive substances including oxidants and glycating agents. Non-enzymatic protein modifications may alter the protein structure often leading to impaired functionality. Although proteolytic systems ensure the removal of modified proteins, the activity of these proteases was shown to decline during the aging process. The additional age-related increase of reactive compounds as a result of impaired antioxidant systems leads to the accumulation of damaged proteins and the formation of protein aggregates. Both, non-enzymatic modified proteins and protein aggregates impair cellular functions and tissue properties by a variety of mechanisms. This is increasingly important in aging and age-related diseases. In this review, we will give an overview on oxidation and glycation of proteins and the function of modified proteins in aggregate formation. Furthermore, their effects as well as their role in aging and age-related diseases will be highlighted." @default.
- W2080694825 created "2016-06-24" @default.
- W2080694825 creator A5008071991 @default.
- W2080694825 creator A5032958494 @default.
- W2080694825 creator A5050771291 @default.
- W2080694825 creator A5087695782 @default.
- W2080694825 date "2014-11-01" @default.
- W2080694825 modified "2023-09-26" @default.
- W2080694825 title "Reprint of “Accumulation of modified proteins and aggregate formation in aging”" @default.
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