FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080694884> ?p ?o ?g. }

• W2080694884 endingPage "7838" @default.
• W2080694884 startingPage "7834" @default.
• W2080694884 abstract "Tight junctions form an intercellular barrier between epithelial cells, serve to separate tissue compartments, and maintain cellular polarity. Paracellular sealing properties vary among cell types and are regulated by undefined mechanisms. Sequence of the full-length cDNA for human ZO-1, the first identified tight junction component, predicts a protein of 1736 aa. The N-terminal 793 aa are homologous to the product of the lethal(1)discs-large-1 (dlg) tumor suppressor gene of Drosophila, located in septate junctions, and to a 95-kDa protein located in the postsynaptic densities of rat brain, PSD-95. All three proteins contain both a src homology region 3 (SH3 domain), previously identified in membrane proteins involved in signal transduction, and a region homologous to guanylate kinase. ZO-1 contains an additional 943-aa C-terminal domain that is proline-rich (14.1%) and contains an alternatively spliced domain, whose expression was previously shown to correlate with variable properties of tight junctions. dlg mutations result in loss of apical-basolateral epithelial cell polarity and in neoplastic growth. These results suggest a protein family specialized for signal transduction on the cytoplasmic surface of intercellular junctions. These results also provide biochemical evidence for similarity between invertebrate septate and vertebrate tight junctions. The C-terminal domain of ZO-1, and its alternatively spliced region, appears to confer variable properties unique to tight junctions." @default.
• W2080694884 created "2016-06-24" @default.
• W2080694884 creator A5024216881 @default.
• W2080694884 creator A5025069791 @default.
• W2080694884 creator A5034557615 @default.
• W2080694884 creator A5057186653 @default.
• W2080694884 creator A5073854417 @default.
• W2080694884 creator A5086901560 @default.
• W2080694884 date "1993-08-15" @default.
• W2080694884 modified "2023-10-14" @default.
• W2080694884 title "The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions." @default.
• W2080694884 cites W1501921984 @default.
• W2080694884 cites W1971377120 @default.
• W2080694884 cites W1972414284 @default.
• W2080694884 cites W1973303883 @default.
• W2080694884 cites W1980943354 @default.
• W2080694884 cites W1981389934 @default.
• W2080694884 cites W1981734045 @default.
• W2080694884 cites W1982974412 @default.
• W2080694884 cites W1985897494 @default.
• W2080694884 cites W2009310436 @default.
• W2080694884 cites W2009890257 @default.
• W2080694884 cites W2024103532 @default.
• W2080694884 cites W2028224423 @default.
• W2080694884 cites W2032574536 @default.
• W2080694884 cites W2042315603 @default.
• W2080694884 cites W2049661143 @default.
• W2080694884 cites W2062026320 @default.
• W2080694884 cites W2063859709 @default.
• W2080694884 cites W2073360590 @default.
• W2080694884 cites W2081950746 @default.
• W2080694884 cites W2088028188 @default.
• W2080694884 cites W2120442500 @default.
• W2080694884 cites W2130516208 @default.
• W2080694884 cites W2146696453 @default.
• W2080694884 cites W2149202604 @default.
• W2080694884 cites W2155579605 @default.
• W2080694884 cites W2168847939 @default.
• W2080694884 cites W2173257592 @default.
• W2080694884 cites W2176544002 @default.
• W2080694884 cites W63651712 @default.
• W2080694884 cites W888493226 @default.
• W2080694884 doi "https://doi.org/10.1073/pnas.90.16.7834" @default.
• W2080694884 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/47237" @default.
• W2080694884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8395056" @default.
• W2080694884 hasPublicationYear "1993" @default.
• W2080694884 type Work @default.
• W2080694884 sameAs 2080694884 @default.
• W2080694884 citedByCount "442" @default.
• W2080694884 countsByYear W20806948842012 @default.
• W2080694884 countsByYear W20806948842013 @default.
• W2080694884 countsByYear W20806948842014 @default.
• W2080694884 countsByYear W20806948842015 @default.
• W2080694884 countsByYear W20806948842016 @default.
• W2080694884 countsByYear W20806948842017 @default.
• W2080694884 countsByYear W20806948842018 @default.
• W2080694884 countsByYear W20806948842019 @default.
• W2080694884 countsByYear W20806948842020 @default.
• W2080694884 countsByYear W20806948842021 @default.
• W2080694884 countsByYear W20806948842022 @default.
• W2080694884 countsByYear W20806948842023 @default.
• W2080694884 crossrefType "journal-article" @default.
• W2080694884 hasAuthorship W2080694884A5024216881 @default.
• W2080694884 hasAuthorship W2080694884A5025069791 @default.
• W2080694884 hasAuthorship W2080694884A5034557615 @default.
• W2080694884 hasAuthorship W2080694884A5057186653 @default.
• W2080694884 hasAuthorship W2080694884A5073854417 @default.
• W2080694884 hasAuthorship W2080694884A5086901560 @default.
• W2080694884 hasBestOaLocation W20806948842 @default.
• W2080694884 hasConcept C108636557 @default.
• W2080694884 hasConcept C118322738 @default.
• W2080694884 hasConcept C1491633281 @default.
• W2080694884 hasConcept C149402561 @default.
• W2080694884 hasConcept C158157758 @default.
• W2080694884 hasConcept C177779419 @default.
• W2080694884 hasConcept C196347352 @default.
• W2080694884 hasConcept C201508349 @default.
• W2080694884 hasConcept C29350253 @default.
• W2080694884 hasConcept C51872919 @default.
• W2080694884 hasConcept C53645450 @default.
• W2080694884 hasConcept C54355233 @default.
• W2080694884 hasConcept C62478195 @default.
• W2080694884 hasConcept C79879829 @default.
• W2080694884 hasConcept C86803240 @default.
• W2080694884 hasConcept C95444343 @default.
• W2080694884 hasConceptScore W2080694884C108636557 @default.
• W2080694884 hasConceptScore W2080694884C118322738 @default.
• W2080694884 hasConceptScore W2080694884C1491633281 @default.
• W2080694884 hasConceptScore W2080694884C149402561 @default.
• W2080694884 hasConceptScore W2080694884C158157758 @default.
• W2080694884 hasConceptScore W2080694884C177779419 @default.
• W2080694884 hasConceptScore W2080694884C196347352 @default.
• W2080694884 hasConceptScore W2080694884C201508349 @default.
• W2080694884 hasConceptScore W2080694884C29350253 @default.
• W2080694884 hasConceptScore W2080694884C51872919 @default.
• W2080694884 hasConceptScore W2080694884C53645450 @default.
• W2080694884 hasConceptScore W2080694884C54355233 @default.
• W2080694884 hasConceptScore W2080694884C62478195 @default.

• next