FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080696565> ?p ?o ?g. }

• W2080696565 endingPage "336" @default.
• W2080696565 startingPage "332" @default.
• W2080696565 abstract "A new class of HCV NS3/4a protease inhibitors containing a P2 to P4 macrocyclic constraint was designed using a molecular modeling-derived strategy. Building on the profile of previous clinical compounds and exploring the P2 and linker regions of the series allowed for optimization of broad genotype and mutant enzyme potency, cellular activity, and rat liver exposure following oral dosing. These studies led to the identification of clinical candidate 15 (MK-5172), which is active against genotype 1-3 NS3/4a and clinically relevant mutant enzymes and has good plasma exposure and excellent liver exposure in multiple species." @default.
• W2080696565 created "2016-06-24" @default.
• W2080696565 creator A5002399883 @default.
• W2080696565 creator A5004460784 @default.
• W2080696565 creator A5006011924 @default.
• W2080696565 creator A5007479812 @default.
• W2080696565 creator A5014074447 @default.
• W2080696565 creator A5022667959 @default.
• W2080696565 creator A5023534006 @default.
• W2080696565 creator A5026982612 @default.
• W2080696565 creator A5027522202 @default.
• W2080696565 creator A5033679363 @default.
• W2080696565 creator A5033705171 @default.
• W2080696565 creator A5036690484 @default.
• W2080696565 creator A5036851868 @default.
• W2080696565 creator A5037628202 @default.
• W2080696565 creator A5039571906 @default.
• W2080696565 creator A5043021448 @default.
• W2080696565 creator A5044099332 @default.
• W2080696565 creator A5047090164 @default.
• W2080696565 creator A5051329481 @default.
• W2080696565 creator A5053676016 @default.
• W2080696565 creator A5056237284 @default.
• W2080696565 creator A5057507889 @default.
• W2080696565 creator A5060422552 @default.
• W2080696565 creator A5062600898 @default.
• W2080696565 creator A5068165067 @default.
• W2080696565 creator A5068647055 @default.
• W2080696565 creator A5072995803 @default.
• W2080696565 creator A5075397807 @default.
• W2080696565 creator A5075540393 @default.
• W2080696565 creator A5081968041 @default.
• W2080696565 creator A5083000467 @default.
• W2080696565 creator A5085651304 @default.
• W2080696565 creator A5086592810 @default.
• W2080696565 creator A5089311313 @default.
• W2080696565 creator A5090176699 @default.
• W2080696565 date "2012-03-02" @default.
• W2080696565 modified "2023-10-18" @default.
• W2080696565 title "Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor" @default.
• W2080696565 cites W1966043736 @default.
• W2080696565 cites W1966522777 @default.
• W2080696565 cites W2006243081 @default.
• W2080696565 cites W2009775127 @default.
• W2080696565 cites W2013411037 @default.
• W2080696565 cites W2064745369 @default.
• W2080696565 cites W2091026598 @default.
• W2080696565 cites W2112876622 @default.
• W2080696565 cites W2140231399 @default.
• W2080696565 cites W2140369033 @default.
• W2080696565 cites W2142684817 @default.
• W2080696565 cites W2145130602 @default.
• W2080696565 cites W2159414436 @default.
• W2080696565 cites W2160114627 @default.
• W2080696565 cites W2163503894 @default.
• W2080696565 cites W2953343485 @default.
• W2080696565 cites W2953356135 @default.
• W2080696565 doi "https://doi.org/10.1021/ml300017p" @default.
• W2080696565 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4025840" @default.
• W2080696565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24900473" @default.
• W2080696565 hasPublicationYear "2012" @default.
• W2080696565 type Work @default.
• W2080696565 sameAs 2080696565 @default.
• W2080696565 citedByCount "171" @default.
• W2080696565 countsByYear W20806965652012 @default.
• W2080696565 countsByYear W20806965652013 @default.
• W2080696565 countsByYear W20806965652014 @default.
• W2080696565 countsByYear W20806965652015 @default.
• W2080696565 countsByYear W20806965652016 @default.
• W2080696565 countsByYear W20806965652017 @default.
• W2080696565 countsByYear W20806965652018 @default.
• W2080696565 countsByYear W20806965652019 @default.
• W2080696565 countsByYear W20806965652020 @default.
• W2080696565 countsByYear W20806965652021 @default.
• W2080696565 countsByYear W20806965652022 @default.
• W2080696565 countsByYear W20806965652023 @default.
• W2080696565 crossrefType "journal-article" @default.
• W2080696565 hasAuthorship W2080696565A5002399883 @default.
• W2080696565 hasAuthorship W2080696565A5004460784 @default.
• W2080696565 hasAuthorship W2080696565A5006011924 @default.
• W2080696565 hasAuthorship W2080696565A5007479812 @default.
• W2080696565 hasAuthorship W2080696565A5014074447 @default.
• W2080696565 hasAuthorship W2080696565A5022667959 @default.
• W2080696565 hasAuthorship W2080696565A5023534006 @default.
• W2080696565 hasAuthorship W2080696565A5026982612 @default.
• W2080696565 hasAuthorship W2080696565A5027522202 @default.
• W2080696565 hasAuthorship W2080696565A5033679363 @default.
• W2080696565 hasAuthorship W2080696565A5033705171 @default.
• W2080696565 hasAuthorship W2080696565A5036690484 @default.
• W2080696565 hasAuthorship W2080696565A5036851868 @default.
• W2080696565 hasAuthorship W2080696565A5037628202 @default.
• W2080696565 hasAuthorship W2080696565A5039571906 @default.
• W2080696565 hasAuthorship W2080696565A5043021448 @default.
• W2080696565 hasAuthorship W2080696565A5044099332 @default.
• W2080696565 hasAuthorship W2080696565A5047090164 @default.
• W2080696565 hasAuthorship W2080696565A5051329481 @default.
• W2080696565 hasAuthorship W2080696565A5053676016 @default.
• W2080696565 hasAuthorship W2080696565A5056237284 @default.

• next