FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080697828> ?p ?o ?g. }

• W2080697828 abstract "The role of newly synthesized RNA in the differentiation of granulosa cells isolated from diethylstilbestrol-treated immature rats was studied during culture with actinomycin D. Choleragen-induced LH receptor formation and cGMP production at 48 h were completely inhibited by actinomycin D (greater than or equal to 100 ng/ml) added as late as 20 h after the initiation of culture and were partially reduced by addition of the antibiotic from 30-48 h. In contrast, addition of actinomycin D to freshly prepared cells enhanced choleragen-stimulated cAMP accumulation during the 48-h culture period. This effect was caused by both elevation of adenylate cyclase activity at 3 and 6 h of culture and inhibition of choleragen-induced phosphodiesterase activity during culture. The increase in cAMP production by actinomycin D was confined to the first few hours of culture, since the antibiotic did not enhance cAMP levels when added after 3 h and significantly reduced cAMP accumulation when added from 20-48 h of culture. Actinomycin D inhibited choleragen-stimulated incorporation of [3H]uridine into RNA of freshly prepared cells by 65% and reduced both RNA synthesis and incorporation of [3H]leucine into protein at 20 and 48 h of culture by approximately 90%. In untreated cells, RNA and protein synthesis and phosphodiesterase activity increased to a larger extent from 20-48 h than after choleragen treatment, but did not lead to elevated cAMP levels or LH receptors. These results suggest that the cAMP-induced syntheses of RNA and protein that are specific for increases in cGMP production and LH receptor formation occur predominantly during the second day of granulosa cell culture. In contrast, cAMP production can be markedly altered by changes in RNA and protein syntheses during the first hours of culture." @default.
• W2080697828 created "2016-06-24" @default.
• W2080697828 creator A5007314582 @default.
• W2080697828 creator A5043312281 @default.
• W2080697828 creator A5058374222 @default.
• W2080697828 creator A5085269523 @default.
• W2080697828 date "1984-09-01" @default.
• W2080697828 modified "2023-09-24" @default.
• W2080697828 title "Dependence of Cyclic Nucleotide Production and Luteinizing Hormone Receptor Formation upon Ribonucleic Acid Synthesis in Cultured Rat Granulosa Cells" @default.
• W2080697828 cites W120899387 @default.
• W2080697828 cites W1488242159 @default.
• W2080697828 cites W1523262309 @default.
• W2080697828 cites W1532668225 @default.
• W2080697828 cites W1550914515 @default.
• W2080697828 cites W1565441789 @default.
• W2080697828 cites W1575806031 @default.
• W2080697828 cites W1705130164 @default.
• W2080697828 cites W1971932969 @default.
• W2080697828 cites W1973166842 @default.
• W2080697828 cites W1983327325 @default.
• W2080697828 cites W1985394131 @default.
• W2080697828 cites W1986425464 @default.
• W2080697828 cites W1996238789 @default.
• W2080697828 cites W1996668195 @default.
• W2080697828 cites W2006827369 @default.
• W2080697828 cites W2021445249 @default.
• W2080697828 cites W2025264246 @default.
• W2080697828 cites W2032117221 @default.
• W2080697828 cites W2036917468 @default.
• W2080697828 cites W2043178059 @default.
• W2080697828 cites W2044351916 @default.
• W2080697828 cites W2048996063 @default.
• W2080697828 cites W2063369849 @default.
• W2080697828 cites W2065647047 @default.
• W2080697828 cites W2075676530 @default.
• W2080697828 cites W2078711269 @default.
• W2080697828 cites W2081487791 @default.
• W2080697828 cites W2092921944 @default.
• W2080697828 cites W2105354674 @default.
• W2080697828 cites W2107529467 @default.
• W2080697828 cites W2133507870 @default.
• W2080697828 cites W2137123290 @default.
• W2080697828 cites W27669850 @default.
• W2080697828 cites W3021645154 @default.
• W2080697828 cites W343065178 @default.
• W2080697828 cites W572878370 @default.
• W2080697828 doi "https://doi.org/10.1210/endo-115-3-904" @default.
• W2080697828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6204855" @default.
• W2080697828 hasPublicationYear "1984" @default.
• W2080697828 type Work @default.
• W2080697828 sameAs 2080697828 @default.
• W2080697828 citedByCount "5" @default.
• W2080697828 crossrefType "journal-article" @default.
• W2080697828 hasAuthorship W2080697828A5007314582 @default.
• W2080697828 hasAuthorship W2080697828A5043312281 @default.
• W2080697828 hasAuthorship W2080697828A5058374222 @default.
• W2080697828 hasAuthorship W2080697828A5085269523 @default.
• W2080697828 hasConcept C104317684 @default.
• W2080697828 hasConcept C126322002 @default.
• W2080697828 hasConcept C134018914 @default.
• W2080697828 hasConcept C170493617 @default.
• W2080697828 hasConcept C180526460 @default.
• W2080697828 hasConcept C181199279 @default.
• W2080697828 hasConcept C2776695378 @default.
• W2080697828 hasConcept C2778128677 @default.
• W2080697828 hasConcept C2778575703 @default.
• W2080697828 hasConcept C2781259782 @default.
• W2080697828 hasConcept C3675279 @default.
• W2080697828 hasConcept C54355233 @default.
• W2080697828 hasConcept C55493867 @default.
• W2080697828 hasConcept C62826618 @default.
• W2080697828 hasConcept C67705224 @default.
• W2080697828 hasConcept C71315377 @default.
• W2080697828 hasConcept C71924100 @default.
• W2080697828 hasConcept C81885089 @default.
• W2080697828 hasConcept C86803240 @default.
• W2080697828 hasConceptScore W2080697828C104317684 @default.
• W2080697828 hasConceptScore W2080697828C126322002 @default.
• W2080697828 hasConceptScore W2080697828C134018914 @default.
• W2080697828 hasConceptScore W2080697828C170493617 @default.
• W2080697828 hasConceptScore W2080697828C180526460 @default.
• W2080697828 hasConceptScore W2080697828C181199279 @default.
• W2080697828 hasConceptScore W2080697828C2776695378 @default.
• W2080697828 hasConceptScore W2080697828C2778128677 @default.
• W2080697828 hasConceptScore W2080697828C2778575703 @default.
• W2080697828 hasConceptScore W2080697828C2781259782 @default.
• W2080697828 hasConceptScore W2080697828C3675279 @default.
• W2080697828 hasConceptScore W2080697828C54355233 @default.
• W2080697828 hasConceptScore W2080697828C55493867 @default.
• W2080697828 hasConceptScore W2080697828C62826618 @default.
• W2080697828 hasConceptScore W2080697828C67705224 @default.
• W2080697828 hasConceptScore W2080697828C71315377 @default.
• W2080697828 hasConceptScore W2080697828C71924100 @default.
• W2080697828 hasConceptScore W2080697828C81885089 @default.
• W2080697828 hasConceptScore W2080697828C86803240 @default.
• W2080697828 hasLocation W20806978281 @default.
• W2080697828 hasLocation W20806978282 @default.
• W2080697828 hasOpenAccess W2080697828 @default.
• W2080697828 hasPrimaryLocation W20806978281 @default.
• W2080697828 hasRelatedWork W1500100952 @default.

• next