FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080702925> ?p ?o ?g. }

• W2080702925 endingPage "162" @default.
• W2080702925 startingPage "156" @default.
• W2080702925 abstract "Interferon (IFN) dramatically reduces both SIV and HIV-1 replicationin vitro. However, we previously found that whereas IFN treatment of SIV-infected cells results in a decrease in the level of viral RNA, IFN treatment of HIV-1-infected cells has no effect on viral RNA expression but rather leads to a decrease in viral protein stability and a deregulation of polyprotein processing (M. B. Agy, R. L. Acker, C. H. Sherbert, and M.G. Katze,Virology214, 379–386, 1995). To more closely define the stage of SIV replication adversely affected by IFN, we used several approaches, including PCR amplification, to examine the effects of IFN on viral DNA synthesis and integration in MT4 and 174 × CEM cells synchronously infected with SIV. Unexpectedly, we found that IFN blocked the synthesis of viral DNA in SIV-infected cells but appeared to have no effect on HIV-1 DNA synthesis. Using a p27 ELISA, we demonstrated that IFN had no effect on the attachment of SIV to MT4 cells. Thus, our results indicate that IFN blocks an early stage of SIV replication, at a step between attachment and reverse transcription. To our knowledge this is the first report to examine the effects of IFN on discrete stages of the SIV life cycle." @default.
• W2080702925 created "2016-06-24" @default.
• W2080702925 creator A5036980616 @default.
• W2080702925 creator A5049808123 @default.
• W2080702925 creator A5064852161 @default.
• W2080702925 date "1998-02-01" @default.
• W2080702925 modified "2023-09-28" @default.
• W2080702925 title "Interferon Treatment Inhibits the Replication of Simian Immunodeficiency Virus at an Early Stage: Evidence for a Block between Attachment and Reverse Transcription" @default.
• W2080702925 cites W1500808920 @default.
• W2080702925 cites W1540303400 @default.
• W2080702925 cites W1599767906 @default.
• W2080702925 cites W1661847997 @default.
• W2080702925 cites W1858240683 @default.
• W2080702925 cites W1965019797 @default.
• W2080702925 cites W1967446284 @default.
• W2080702925 cites W1974029911 @default.
• W2080702925 cites W1977282539 @default.
• W2080702925 cites W1981440980 @default.
• W2080702925 cites W1981644527 @default.
• W2080702925 cites W1984998344 @default.
• W2080702925 cites W1987888541 @default.
• W2080702925 cites W1996183144 @default.
• W2080702925 cites W2006416369 @default.
• W2080702925 cites W2008585820 @default.
• W2080702925 cites W2014666617 @default.
• W2080702925 cites W2015326137 @default.
• W2080702925 cites W2017190280 @default.
• W2080702925 cites W2018113410 @default.
• W2080702925 cites W2019801008 @default.
• W2080702925 cites W2028362497 @default.
• W2080702925 cites W2029812035 @default.
• W2080702925 cites W2031286781 @default.
• W2080702925 cites W2037104820 @default.
• W2080702925 cites W2049444392 @default.
• W2080702925 cites W2052553744 @default.
• W2080702925 cites W2067730594 @default.
• W2080702925 cites W2068151486 @default.
• W2080702925 cites W2077057049 @default.
• W2080702925 cites W2077077811 @default.
• W2080702925 cites W2082206844 @default.
• W2080702925 cites W2086706485 @default.
• W2080702925 cites W2087004183 @default.
• W2080702925 cites W2090822316 @default.
• W2080702925 cites W2091782886 @default.
• W2080702925 cites W2096092788 @default.
• W2080702925 cites W2103796054 @default.
• W2080702925 cites W2105209643 @default.
• W2080702925 cites W2106513047 @default.
• W2080702925 cites W2142603344 @default.
• W2080702925 cites W2147945419 @default.
• W2080702925 cites W2152074759 @default.
• W2080702925 cites W2161299455 @default.
• W2080702925 cites W2164592489 @default.
• W2080702925 cites W2168837823 @default.
• W2080702925 cites W2321068382 @default.
• W2080702925 cites W4233721986 @default.
• W2080702925 cites W4294216491 @default.
• W2080702925 doi "https://doi.org/10.1006/viro.1997.8964" @default.
• W2080702925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9454726" @default.
• W2080702925 hasPublicationYear "1998" @default.
• W2080702925 type Work @default.
• W2080702925 sameAs 2080702925 @default.
• W2080702925 citedByCount "18" @default.
• W2080702925 countsByYear W20807029252013 @default.
• W2080702925 countsByYear W20807029252015 @default.
• W2080702925 countsByYear W20807029252016 @default.
• W2080702925 countsByYear W20807029252017 @default.
• W2080702925 countsByYear W20807029252018 @default.
• W2080702925 crossrefType "journal-article" @default.
• W2080702925 hasAuthorship W2080702925A5036980616 @default.
• W2080702925 hasAuthorship W2080702925A5049808123 @default.
• W2080702925 hasAuthorship W2080702925A5064852161 @default.
• W2080702925 hasBestOaLocation W20807029251 @default.
• W2080702925 hasConcept C104317684 @default.
• W2080702925 hasConcept C138885662 @default.
• W2080702925 hasConcept C140704245 @default.
• W2080702925 hasConcept C156719811 @default.
• W2080702925 hasConcept C159047783 @default.
• W2080702925 hasConcept C179926584 @default.
• W2080702925 hasConcept C2522874641 @default.
• W2080702925 hasConcept C25897203 @default.
• W2080702925 hasConcept C2776178377 @default.
• W2080702925 hasConcept C2777995582 @default.
• W2080702925 hasConcept C41895202 @default.
• W2080702925 hasConcept C54355233 @default.
• W2080702925 hasConcept C67705224 @default.
• W2080702925 hasConcept C86803240 @default.
• W2080702925 hasConceptScore W2080702925C104317684 @default.
• W2080702925 hasConceptScore W2080702925C138885662 @default.
• W2080702925 hasConceptScore W2080702925C140704245 @default.
• W2080702925 hasConceptScore W2080702925C156719811 @default.
• W2080702925 hasConceptScore W2080702925C159047783 @default.
• W2080702925 hasConceptScore W2080702925C179926584 @default.
• W2080702925 hasConceptScore W2080702925C2522874641 @default.
• W2080702925 hasConceptScore W2080702925C25897203 @default.
• W2080702925 hasConceptScore W2080702925C2776178377 @default.
• W2080702925 hasConceptScore W2080702925C2777995582 @default.
• W2080702925 hasConceptScore W2080702925C41895202 @default.

• next