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- W2080703352 abstract "Abstract Tissue-type plasminogen activator (t-PA) plays a pivotal role in the onset of fibrinolysis. Regulation of t-PA activity in the bloodstream occurs at various levels, including release from the endothelium and, to some extent, interaction with a specific inhibitor, PAI-1. Modulation of the fibrinolytic capacity in plasma (endogenous fibrinolysis) would be a powerful means in preventing thrombosis. This paper describes the use of cultured human endothelial cells and hepatocytes as in vitro model systems to study regulation of t-PA and PAI-1 synthesis. Evidence is provided that these models represent useful alternatives for the use of experimental animals in finding compounds that might stimulate endogenous fibrinolysis in humans. These in vitro systems allow detailed studies of regulatory mechanisms, and it is shown that the t-PA synthesizing capacity of endothelial cells is only partially exploited, suggesting that stimulation of endogenous fibrinolysis is feasible. Also, some progress has been made in developing an in vitro system for studying the acute, i.e. within minutes, release of t-PA from endothelial cells and the state of the art of this model is discussed." @default.
- W2080703352 created "2016-06-24" @default.
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- W2080703352 date "1990-01-01" @default.
- W2080703352 modified "2023-09-27" @default.
- W2080703352 title "The use of cultured human endothelial cells and hepatocytes as an in vitro model system to study modulation of endogenous fibrinolysis" @default.
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- W2080703352 doi "https://doi.org/10.1016/0268-9499(90)90352-k" @default.
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