FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080704367> ?p ?o ?g. }

• W2080704367 endingPage "454" @default.
• W2080704367 startingPage "448" @default.
• W2080704367 abstract "Acute treatment with extracts of Hypericum perforatum, the common plant usually called St. John's Wort, reduces voluntary ethanol intake in Marchigian Sardinian alcohol-preferring (msP) rats and acts synergistically with opioid receptor antagonists to further attenuate ethanol consumption. The present study evaluated the effect of chronic (once a day for 12 days) intragastric administration of a CO2 Hypericum perforatum extract (HPCO2), given alone or combined with naltrexone (NTX), on ethanol intake offered 2h/day in msP rats. Chronic treatment with HPCO2 markedly reduced ethanol intake at the dose of 125, but not at 7 mg/kg; the effect of 125 mg/kg was observed since the first day of treatment and remained constant across the 12 days. The same dose of HPCO2 slightly reduced the simultaneous intake of food only on day 3 and day 11 of treatment. Treated rats promptly recovered baseline ethanol intake when treatment did not precede access to ethanol (on day 8) or after the end of treatment (day 13 and day 14), suggesting that HPCO2 administrations did not induce conditioned aversion to alcohol. Chronic intraperitoneal treatment with NTX reduced ethanol intake at 3, but not at 0.5mg/kg. The synergistic effect on ethanol intake of HPCO2 and NTX was evident also in conditions of chronic treatment. HPCO2, 7 mg/kg, and NTX, 0.5mg/kg, evoked a pronounced and statistically significant reduction of ethanol intake, while being inactive. The effect on ethanol intake of the combined treatment remained stable over the 12 days of treatment; food intake was slightly reduced only on day 3 and on day 7 in response to 125 mg/kg of HPCO2 combined with NTX 0.5mg/kg, but no difference in body weight between controls and treated rats was observed at the end of treatment. Following 12-day treatment with 125 mg/kg of HPCO2, no difference was observed in the responsivity of msP rats to the effect on ethanol intake of several doses of the extract. In conclusion, the present results provide evidence for a selective and pronounced effect of HPCO2, alone or combined with naltrexone, on ethanol intake in conditions of chronic treatment, without development of tolerance. These findings further support the view that clinical trials for extracts of Hypericum perforatum in the treatment of alcoholism should be considered." @default.
• W2080704367 created "2016-06-24" @default.
• W2080704367 creator A5000760831 @default.
• W2080704367 creator A5011458635 @default.
• W2080704367 creator A5012529212 @default.
• W2080704367 creator A5061610888 @default.
• W2080704367 date "2005-09-01" @default.
• W2080704367 modified "2023-10-02" @default.
• W2080704367 title "Reduction of ethanol intake by chronic treatment with Hypericum perforatum, alone or combined with naltrexone in rats" @default.
• W2080704367 cites W1965472158 @default.
• W2080704367 cites W1972659523 @default.
• W2080704367 cites W1978747889 @default.
• W2080704367 cites W1978871608 @default.
• W2080704367 cites W1979476242 @default.
• W2080704367 cites W1988000040 @default.
• W2080704367 cites W1990621985 @default.
• W2080704367 cites W1994066070 @default.
• W2080704367 cites W2014048522 @default.
• W2080704367 cites W2015046028 @default.
• W2080704367 cites W2018335005 @default.
• W2080704367 cites W2019554028 @default.
• W2080704367 cites W2023205898 @default.
• W2080704367 cites W2036154979 @default.
• W2080704367 cites W2045341302 @default.
• W2080704367 cites W2051486461 @default.
• W2080704367 cites W2061729026 @default.
• W2080704367 cites W2070282049 @default.
• W2080704367 cites W2090095169 @default.
• W2080704367 cites W2090388536 @default.
• W2080704367 cites W2093559862 @default.
• W2080704367 cites W2097161191 @default.
• W2080704367 cites W2104538950 @default.
• W2080704367 cites W2108123988 @default.
• W2080704367 cites W2108135546 @default.
• W2080704367 cites W2108173576 @default.
• W2080704367 cites W2121179976 @default.
• W2080704367 cites W2123220191 @default.
• W2080704367 cites W2147721154 @default.
• W2080704367 cites W2160739753 @default.
• W2080704367 cites W2169418154 @default.
• W2080704367 cites W2331395765 @default.
• W2080704367 cites W8706462 @default.
• W2080704367 doi "https://doi.org/10.1177/0269881105056519" @default.
• W2080704367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16166181" @default.
• W2080704367 hasPublicationYear "2005" @default.
• W2080704367 type Work @default.
• W2080704367 sameAs 2080704367 @default.
• W2080704367 citedByCount "19" @default.
• W2080704367 countsByYear W20807043672012 @default.
• W2080704367 countsByYear W20807043672013 @default.
• W2080704367 countsByYear W20807043672015 @default.
• W2080704367 countsByYear W20807043672016 @default.
• W2080704367 countsByYear W20807043672017 @default.
• W2080704367 countsByYear W20807043672018 @default.
• W2080704367 countsByYear W20807043672019 @default.
• W2080704367 countsByYear W20807043672022 @default.
• W2080704367 crossrefType "journal-article" @default.
• W2080704367 hasAuthorship W2080704367A5000760831 @default.
• W2080704367 hasAuthorship W2080704367A5011458635 @default.
• W2080704367 hasAuthorship W2080704367A5012529212 @default.
• W2080704367 hasAuthorship W2080704367A5061610888 @default.
• W2080704367 hasConcept C126322002 @default.
• W2080704367 hasConcept C170493617 @default.
• W2080704367 hasConcept C185592680 @default.
• W2080704367 hasConcept C2776651039 @default.
• W2080704367 hasConcept C2777972943 @default.
• W2080704367 hasConcept C2778215561 @default.
• W2080704367 hasConcept C2780161600 @default.
• W2080704367 hasConcept C2781063702 @default.
• W2080704367 hasConcept C2781066024 @default.
• W2080704367 hasConcept C55493867 @default.
• W2080704367 hasConcept C556039675 @default.
• W2080704367 hasConcept C71924100 @default.
• W2080704367 hasConcept C98274493 @default.
• W2080704367 hasConceptScore W2080704367C126322002 @default.
• W2080704367 hasConceptScore W2080704367C170493617 @default.
• W2080704367 hasConceptScore W2080704367C185592680 @default.
• W2080704367 hasConceptScore W2080704367C2776651039 @default.
• W2080704367 hasConceptScore W2080704367C2777972943 @default.
• W2080704367 hasConceptScore W2080704367C2778215561 @default.
• W2080704367 hasConceptScore W2080704367C2780161600 @default.
• W2080704367 hasConceptScore W2080704367C2781063702 @default.
• W2080704367 hasConceptScore W2080704367C2781066024 @default.
• W2080704367 hasConceptScore W2080704367C55493867 @default.
• W2080704367 hasConceptScore W2080704367C556039675 @default.
• W2080704367 hasConceptScore W2080704367C71924100 @default.
• W2080704367 hasConceptScore W2080704367C98274493 @default.
• W2080704367 hasIssue "5" @default.
• W2080704367 hasLocation W20807043671 @default.
• W2080704367 hasLocation W20807043672 @default.
• W2080704367 hasOpenAccess W2080704367 @default.
• W2080704367 hasPrimaryLocation W20807043671 @default.
• W2080704367 hasRelatedWork W1976012957 @default.
• W2080704367 hasRelatedWork W2000904856 @default.
• W2080704367 hasRelatedWork W2015612551 @default.
• W2080704367 hasRelatedWork W2018501808 @default.
• W2080704367 hasRelatedWork W2029546898 @default.
• W2080704367 hasRelatedWork W2062551448 @default.

• next