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- W2080709390 abstract "Multiple myeloma is the second most common hematological malignancy and the most frequent cancer to involve the skeleton. Multiple myeloma bone disease (MMBD) is characterized by abnormal bone remodeling with dysfunction of both bone resorption and bone formation, and thus can be used as a paradigm for other inflammatory bone diseases, and the regulation of osteoclasts and osteoblasts in malignancy. Studies of MMBD have identified novel regulators that increase osteoclastogenesis and osteoclast function, repress osteoblast differentiation, increase angiogenesis, or permanently alter stromal cells. This review will discuss the current understanding of mechanisms of osteoclast and osteoblast regulation in MMBD, and therapeutic approaches currently in use and under development that target mediators of bone destruction and blockade of bone formation for myeloma patients, including new anabolic therapies." @default.
- W2080709390 created "2016-06-24" @default.
- W2080709390 creator A5019561937 @default.
- W2080709390 creator A5026804242 @default.
- W2080709390 creator A5066907686 @default.
- W2080709390 date "2012-08-01" @default.
- W2080709390 modified "2023-09-27" @default.
- W2080709390 title "Mechanisms of multiple myeloma bone disease" @default.
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- W2080709390 doi "https://doi.org/10.1038/bonekey.2012.135" @default.
- W2080709390 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3727863" @default.