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- W2080724912 abstract "to test the hypothesis that there is a negative association between serum levels of lipoprotein(a) (Lp(a)) and elastin-derived peptides (EDP) as well as matrix metalloproteinase (MMP)-9 activation in the aneurysm wall in patients with asymptomatic abdominal aortic aneurysms (AAA).from 30 patients operated for asymptomatic AAAs, preoperative serum samples and AAA biopsies were collected. Lp(a) (mg/L) and EDP (ng/ml) in serum were measured by enzyme linked immunosorbent assays. MMP-9 activity (arbitrary units) in the AAA wall was measured by gelatin zymography and the ratio: active MMP-9/total MMP-9 were calculated.there was a significant negative correlation (Spearman's rho) between serum levels of Lp(a) and EDP (r= -0.707, p<0.001), as well as the share of activated MMP-9 (r= -0.461, p=0.01) in the AAA wall.this preliminary study indicate that Lp(a) inhibit elastolysis in asymptomatic AAA." @default.
- W2080724912 created "2016-06-24" @default.
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- W2080724912 date "2003-10-01" @default.
- W2080724912 modified "2023-10-14" @default.
- W2080724912 title "Does Lipoprotein(a) Inhibit Elastolysis in Abdominal Aortic Aneurysms?" @default.
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- W2080724912 doi "https://doi.org/10.1016/s1078-5884(03)00178-3" @default.
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