Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080735778> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2080735778 endingPage "1573" @default.
- W2080735778 startingPage "1565" @default.
- W2080735778 abstract "The primary immune response toward internal parasites and other large foreign objects that enter the insect hemocoel is encapsulation. Prior studies indicated that granular cells and plasmatocytes are the two hemocyte types required for capsule formation by the moth Pseudoplusia includens (Lepidoptera: Noctuidae). Capsules formed by P. includens also have a defined architecture with primarily granular cells attaching directly to the target, multiple layers of plasmatocytes adhering to this inner layer of granular cells, and a monolayer of granular cells attaching to the capsule periphery. Dye-exclusion assays indicated that granular cells die shortly after attaching to the capsule periphery, leaving a basal lamina-like layer around the capsule. In examining the mechanisms underlying granular cell death, we found that culture medium preconditioned by plasmatocytes induced apoptosis of granular cells. Characteristics of plasmatocyte-induced apoptosis included condensation of chromatin, cell surface blebbing and fragmentation of nuclear DNA. Plasmatocyte-conditioned medium did not induce apoptosis of other hemocyte types, and medium conditioned by other hemocyte types did not induce apoptosis of granular cells. The adhesive state of granular cells and plasmatocytes also affected levels of apoptosis. Conditioned medium from spread plasmatocytes induced higher levels of granular cell apoptosis than medium conditioned by unspread plasmatocytes. Reciprocally, spread granular cells underwent significantly higher rates of apoptosis than unspread granular cells in medium conditioned by spread plasmatocytes. In situ analysis indicated that granular cells on the periphery of capsules also undergo apoptosis. Collectively, our results suggest that spread plasmatocytes release one or more factors that induce apoptosis of granular cells, and that this response is important in the final phases of capsule formation." @default.
- W2080735778 created "2016-06-24" @default.
- W2080735778 creator A5024330606 @default.
- W2080735778 creator A5050516508 @default.
- W2080735778 date "2000-12-01" @default.
- W2080735778 modified "2023-10-02" @default.
- W2080735778 title "Plasmatocytes from the moth Pseudoplusia includens induce apoptosis of granular cells" @default.
- W2080735778 cites W1589917428 @default.
- W2080735778 cites W1942214720 @default.
- W2080735778 cites W1969033173 @default.
- W2080735778 cites W1972147459 @default.
- W2080735778 cites W1974555367 @default.
- W2080735778 cites W1999133360 @default.
- W2080735778 cites W2000352412 @default.
- W2080735778 cites W2003006109 @default.
- W2080735778 cites W2003525034 @default.
- W2080735778 cites W2004487378 @default.
- W2080735778 cites W2006307880 @default.
- W2080735778 cites W2038693436 @default.
- W2080735778 cites W2039676996 @default.
- W2080735778 cites W2043226614 @default.
- W2080735778 cites W2046623597 @default.
- W2080735778 cites W2056364034 @default.
- W2080735778 cites W2058093573 @default.
- W2080735778 cites W2058617334 @default.
- W2080735778 cites W2061497413 @default.
- W2080735778 cites W2077327812 @default.
- W2080735778 cites W2079761484 @default.
- W2080735778 cites W2089821789 @default.
- W2080735778 cites W2102059944 @default.
- W2080735778 cites W2145908419 @default.
- W2080735778 cites W2161900824 @default.
- W2080735778 cites W2169089697 @default.
- W2080735778 cites W2169554406 @default.
- W2080735778 cites W2341429009 @default.
- W2080735778 cites W2403271902 @default.
- W2080735778 cites W4229662680 @default.
- W2080735778 doi "https://doi.org/10.1016/s0022-1910(00)00083-4" @default.
- W2080735778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10980302" @default.
- W2080735778 hasPublicationYear "2000" @default.
- W2080735778 type Work @default.
- W2080735778 sameAs 2080735778 @default.
- W2080735778 citedByCount "67" @default.
- W2080735778 countsByYear W20807357782012 @default.
- W2080735778 countsByYear W20807357782013 @default.
- W2080735778 countsByYear W20807357782014 @default.
- W2080735778 countsByYear W20807357782015 @default.
- W2080735778 countsByYear W20807357782016 @default.
- W2080735778 countsByYear W20807357782017 @default.
- W2080735778 countsByYear W20807357782018 @default.
- W2080735778 countsByYear W20807357782019 @default.
- W2080735778 countsByYear W20807357782021 @default.
- W2080735778 countsByYear W20807357782022 @default.
- W2080735778 crossrefType "journal-article" @default.
- W2080735778 hasAuthorship W2080735778A5024330606 @default.
- W2080735778 hasAuthorship W2080735778A5050516508 @default.
- W2080735778 hasConcept C18903297 @default.
- W2080735778 hasConcept C190283241 @default.
- W2080735778 hasConcept C191015642 @default.
- W2080735778 hasConcept C203014093 @default.
- W2080735778 hasConcept C31573885 @default.
- W2080735778 hasConcept C43759708 @default.
- W2080735778 hasConcept C55493867 @default.
- W2080735778 hasConcept C86803240 @default.
- W2080735778 hasConcept C89423630 @default.
- W2080735778 hasConcept C95444343 @default.
- W2080735778 hasConceptScore W2080735778C18903297 @default.
- W2080735778 hasConceptScore W2080735778C190283241 @default.
- W2080735778 hasConceptScore W2080735778C191015642 @default.
- W2080735778 hasConceptScore W2080735778C203014093 @default.
- W2080735778 hasConceptScore W2080735778C31573885 @default.
- W2080735778 hasConceptScore W2080735778C43759708 @default.
- W2080735778 hasConceptScore W2080735778C55493867 @default.
- W2080735778 hasConceptScore W2080735778C86803240 @default.
- W2080735778 hasConceptScore W2080735778C89423630 @default.
- W2080735778 hasConceptScore W2080735778C95444343 @default.
- W2080735778 hasIssue "12" @default.
- W2080735778 hasLocation W20807357781 @default.
- W2080735778 hasLocation W20807357782 @default.
- W2080735778 hasOpenAccess W2080735778 @default.
- W2080735778 hasPrimaryLocation W20807357781 @default.
- W2080735778 hasRelatedWork W1978041418 @default.
- W2080735778 hasRelatedWork W2022297125 @default.
- W2080735778 hasRelatedWork W2030482078 @default.
- W2080735778 hasRelatedWork W2071519641 @default.
- W2080735778 hasRelatedWork W2117519097 @default.
- W2080735778 hasRelatedWork W2161791039 @default.
- W2080735778 hasRelatedWork W2186559937 @default.
- W2080735778 hasRelatedWork W2272046160 @default.
- W2080735778 hasRelatedWork W3158786004 @default.
- W2080735778 hasRelatedWork W4220681557 @default.
- W2080735778 hasVolume "46" @default.
- W2080735778 isParatext "false" @default.
- W2080735778 isRetracted "false" @default.
- W2080735778 magId "2080735778" @default.
- W2080735778 workType "article" @default.