FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080740071> ?p ?o ?g. }

• W2080740071 endingPage "1153" @default.
• W2080740071 startingPage "1147" @default.
• W2080740071 abstract "Abstract Genetic factors are believed to contribute to multiple sclerosis (MS) susceptibility; however, strong evidence implicating intrinsic and environmental factors in the etiopathogenesis of MS also exists. Susceptibility to experimental allergic encephalomyelitis (EAE), the principal animal model of MS, is also influenced by nongenetic factors, including age and season at immunization. This suggests that age- and season-by-gene interactions exist and that different susceptibility loci may influence disease as a function of the two parameters. In this study, linkage analysis based on genome exclusion mapping was carried out using age and season at immunization restricted cohorts of (B10.S × SJL/J) F2 intercross mice in an effort to identify such linkages. Significant linkage of EAE to eae4 and eae5 was detected with 6- to 12-week-old and summer cohorts. In contrast, significant linkage of EAE to eae4 and eae5 was not detected with the &gt;12-week-old and winter/spring populations. Rather, significant linkage to D4Mit203 at 128.50 Mb on chromosome 4 was detected with animals that were &gt;12 weeks old at the time of immunization or were immunized in the winter. This previously unidentified locus has been designated eae36. These results support the existence of age- and season-by-gene-specific interactions in the genetic control of susceptibility to autoimmune inflammatory disease of the central nervous system and suggest that late-onset MS may be immunogenetically distinct." @default.
• W2080740071 created "2016-06-24" @default.
• W2080740071 creator A5019678063 @default.
• W2080740071 creator A5026862562 @default.
• W2080740071 creator A5040494134 @default.
• W2080740071 creator A5071657531 @default.
• W2080740071 date "2006-02-01" @default.
• W2080740071 modified "2023-10-18" @default.
• W2080740071 title "eae36, a Locus on Mouse Chromosome 4, Controls Susceptibility to Experimental Allergic Encephalomyelitis in Older Mice and Mice Immunized in the Winter" @default.
• W2080740071 cites W146385769 @default.
• W2080740071 cites W1530467972 @default.
• W2080740071 cites W1574626486 @default.
• W2080740071 cites W1596721825 @default.
• W2080740071 cites W160460959 @default.
• W2080740071 cites W1608810958 @default.
• W2080740071 cites W1830814020 @default.
• W2080740071 cites W1923296204 @default.
• W2080740071 cites W1945944294 @default.
• W2080740071 cites W1964784067 @default.
• W2080740071 cites W1970862254 @default.
• W2080740071 cites W1970886321 @default.
• W2080740071 cites W1973411765 @default.
• W2080740071 cites W1973951821 @default.
• W2080740071 cites W197630971 @default.
• W2080740071 cites W1981142987 @default.
• W2080740071 cites W1987865123 @default.
• W2080740071 cites W1993914917 @default.
• W2080740071 cites W2002654969 @default.
• W2080740071 cites W2005848078 @default.
• W2080740071 cites W2006540054 @default.
• W2080740071 cites W2008022427 @default.
• W2080740071 cites W2009337725 @default.
• W2080740071 cites W2009701030 @default.
• W2080740071 cites W2009963980 @default.
• W2080740071 cites W2012129851 @default.
• W2080740071 cites W2016945675 @default.
• W2080740071 cites W2018406848 @default.
• W2080740071 cites W2019459040 @default.
• W2080740071 cites W2019926860 @default.
• W2080740071 cites W2020137975 @default.
• W2080740071 cites W2020254327 @default.
• W2080740071 cites W2026167242 @default.
• W2080740071 cites W2027625619 @default.
• W2080740071 cites W2027671137 @default.
• W2080740071 cites W2027721538 @default.
• W2080740071 cites W2027840218 @default.
• W2080740071 cites W2027953381 @default.
• W2080740071 cites W2034337512 @default.
• W2080740071 cites W2042742638 @default.
• W2080740071 cites W2043173334 @default.
• W2080740071 cites W2043464691 @default.
• W2080740071 cites W2045586328 @default.
• W2080740071 cites W2047187919 @default.
• W2080740071 cites W2050297923 @default.
• W2080740071 cites W2051674791 @default.
• W2080740071 cites W2054123742 @default.
• W2080740071 cites W2061941265 @default.
• W2080740071 cites W2075242957 @default.
• W2080740071 cites W2077133009 @default.
• W2080740071 cites W2084876171 @default.
• W2080740071 cites W2086661036 @default.
• W2080740071 cites W2087941260 @default.
• W2080740071 cites W2099579812 @default.
• W2080740071 cites W2106531784 @default.
• W2080740071 cites W2107426014 @default.
• W2080740071 cites W2108499266 @default.
• W2080740071 cites W2125860227 @default.
• W2080740071 cites W2127750024 @default.
• W2080740071 cites W2136371196 @default.
• W2080740071 cites W2153295340 @default.
• W2080740071 cites W2155103277 @default.
• W2080740071 cites W2158288874 @default.
• W2080740071 cites W2161927278 @default.
• W2080740071 cites W2161929126 @default.
• W2080740071 cites W2169255619 @default.
• W2080740071 cites W2186226783 @default.
• W2080740071 cites W2331622432 @default.
• W2080740071 cites W2411836936 @default.
• W2080740071 cites W2885744270 @default.
• W2080740071 cites W4241890711 @default.
• W2080740071 cites W2149128385 @default.
• W2080740071 doi "https://doi.org/10.1534/genetics.105.049049" @default.
• W2080740071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1456213" @default.
• W2080740071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16299394" @default.
• W2080740071 hasPublicationYear "2006" @default.
• W2080740071 type Work @default.
• W2080740071 sameAs 2080740071 @default.
• W2080740071 citedByCount "22" @default.
• W2080740071 countsByYear W20807400712012 @default.
• W2080740071 countsByYear W20807400712013 @default.
• W2080740071 countsByYear W20807400712015 @default.
• W2080740071 countsByYear W20807400712018 @default.
• W2080740071 countsByYear W20807400712020 @default.
• W2080740071 crossrefType "journal-article" @default.
• W2080740071 hasAuthorship W2080740071A5019678063 @default.
• W2080740071 hasAuthorship W2080740071A5026862562 @default.
• W2080740071 hasAuthorship W2080740071A5040494134 @default.
• W2080740071 hasAuthorship W2080740071A5071657531 @default.

• next