FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080752439> ?p ?o ?g. }

• W2080752439 endingPage "188" @default.
• W2080752439 startingPage "180" @default.
• W2080752439 abstract "Aerosol delivery of plasmid DNA to the lungs offers the possibility of direct application of gene preparations to pulmonary surfaces as a means of treating a variety of genetic pulmonary disorders. However, the process of jet nebulization rapidly degrades naked DNA, viral vectors, and many lipid-based formulations. While complexing DNA with cationic lipids has been shown to significantly stabilize plasmid DNA, losses of biological activity often occur during nebulization, severely limiting the efficiency of aerosol delivery of many such complexes. In conjunction with the design of aerosol delivery systems appropriate for DNA delivery, we have developed formulations using polyethyleneimine (PEI, a polycationic polymer) and DNA that result in a high level of pulmonary transfection (10- to 100-fold greater than many cationic lipids) and are stable during nebulization. In addition, these PEI-based formulations exhibit a high degree of specificity for the lungs. The properties of PEI-based formulations that make them resistant to nebulization and efficient as DNA delivery vectors for pulmonary sites have been investigated. Potential applications of this technology, including the use of aerosolized PEI–DNA for genetic immunization, are discussed." @default.
• W2080752439 created "2016-06-24" @default.
• W2080752439 creator A5003436305 @default.
• W2080752439 creator A5007962977 @default.
• W2080752439 creator A5010820446 @default.
• W2080752439 creator A5023954133 @default.
• W2080752439 creator A5024300677 @default.
• W2080752439 creator A5068077099 @default.
• W2080752439 creator A5070954415 @default.
• W2080752439 creator A5087489539 @default.
• W2080752439 date "2000-02-01" @default.
• W2080752439 modified "2023-10-01" @default.
• W2080752439 title "Aerosol Delivery of Robust Polyethyleneimine– DNA Complexes for Gene Therapy and Genetic Immunization" @default.
• W2080752439 cites W1968187293 @default.
• W2080752439 cites W1970594627 @default.
• W2080752439 cites W1983893899 @default.
• W2080752439 cites W1994216034 @default.
• W2080752439 cites W1994294376 @default.
• W2080752439 cites W1996024960 @default.
• W2080752439 cites W2010358964 @default.
• W2080752439 cites W2010655741 @default.
• W2080752439 cites W2019026359 @default.
• W2080752439 cites W2020133844 @default.
• W2080752439 cites W2021559180 @default.
• W2080752439 cites W2023104469 @default.
• W2080752439 cites W2034642422 @default.
• W2080752439 cites W2036354853 @default.
• W2080752439 cites W2040148620 @default.
• W2080752439 cites W2040282775 @default.
• W2080752439 cites W2053965092 @default.
• W2080752439 cites W2056260885 @default.
• W2080752439 cites W2067521571 @default.
• W2080752439 cites W2073537725 @default.
• W2080752439 cites W2074870430 @default.
• W2080752439 cites W2084921885 @default.
• W2080752439 cites W2092447252 @default.
• W2080752439 cites W2142987628 @default.
• W2080752439 cites W2154329741 @default.
• W2080752439 doi "https://doi.org/10.1006/mthe.1999.0021" @default.
• W2080752439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10933929" @default.
• W2080752439 hasPublicationYear "2000" @default.
• W2080752439 type Work @default.
• W2080752439 sameAs 2080752439 @default.
• W2080752439 citedByCount "160" @default.
• W2080752439 countsByYear W20807524392012 @default.
• W2080752439 countsByYear W20807524392013 @default.
• W2080752439 countsByYear W20807524392014 @default.
• W2080752439 countsByYear W20807524392015 @default.
• W2080752439 countsByYear W20807524392016 @default.
• W2080752439 countsByYear W20807524392017 @default.
• W2080752439 countsByYear W20807524392018 @default.
• W2080752439 countsByYear W20807524392019 @default.
• W2080752439 countsByYear W20807524392020 @default.
• W2080752439 countsByYear W20807524392021 @default.
• W2080752439 countsByYear W20807524392022 @default.
• W2080752439 countsByYear W20807524392023 @default.
• W2080752439 crossrefType "journal-article" @default.
• W2080752439 hasAuthorship W2080752439A5003436305 @default.
• W2080752439 hasAuthorship W2080752439A5007962977 @default.
• W2080752439 hasAuthorship W2080752439A5010820446 @default.
• W2080752439 hasAuthorship W2080752439A5023954133 @default.
• W2080752439 hasAuthorship W2080752439A5024300677 @default.
• W2080752439 hasAuthorship W2080752439A5068077099 @default.
• W2080752439 hasAuthorship W2080752439A5070954415 @default.
• W2080752439 hasAuthorship W2080752439A5087489539 @default.
• W2080752439 hasBestOaLocation W20807524391 @default.
• W2080752439 hasConcept C104317684 @default.
• W2080752439 hasConcept C105702510 @default.
• W2080752439 hasConcept C111599444 @default.
• W2080752439 hasConcept C135983454 @default.
• W2080752439 hasConcept C153911025 @default.
• W2080752439 hasConcept C178790620 @default.
• W2080752439 hasConcept C183882617 @default.
• W2080752439 hasConcept C185592680 @default.
• W2080752439 hasConcept C188027245 @default.
• W2080752439 hasConcept C195856716 @default.
• W2080752439 hasConcept C22744801 @default.
• W2080752439 hasConcept C2776954882 @default.
• W2080752439 hasConcept C2779345167 @default.
• W2080752439 hasConcept C54009773 @default.
• W2080752439 hasConcept C552990157 @default.
• W2080752439 hasConcept C55493867 @default.
• W2080752439 hasConcept C82085835 @default.
• W2080752439 hasConcept C86803240 @default.
• W2080752439 hasConceptScore W2080752439C104317684 @default.
• W2080752439 hasConceptScore W2080752439C105702510 @default.
• W2080752439 hasConceptScore W2080752439C111599444 @default.
• W2080752439 hasConceptScore W2080752439C135983454 @default.
• W2080752439 hasConceptScore W2080752439C153911025 @default.
• W2080752439 hasConceptScore W2080752439C178790620 @default.
• W2080752439 hasConceptScore W2080752439C183882617 @default.
• W2080752439 hasConceptScore W2080752439C185592680 @default.
• W2080752439 hasConceptScore W2080752439C188027245 @default.
• W2080752439 hasConceptScore W2080752439C195856716 @default.
• W2080752439 hasConceptScore W2080752439C22744801 @default.
• W2080752439 hasConceptScore W2080752439C2776954882 @default.
• W2080752439 hasConceptScore W2080752439C2779345167 @default.
• W2080752439 hasConceptScore W2080752439C54009773 @default.

• next