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- W2080752929 abstract "Recent applications of genomic approaches to long-standing problems have set the stage for potential breakthroughs in gene regulation, and in providing new insights into disease mechanisms and possible intervention strategies. The details of how DNA is packaged in order to provide a compact organized state in the cell nucleus, while at the same time allowing both constitutive and tissue-specific gene regulation and other cellular functions, have eluded us. This difficulty is not surprising owing to the complexity of the problem. Nevertheless, many chromatin structure and nuclear organization models have been proposed over the years, and models tend to have a large influence on how we think about gene regulation and other cellular mechanisms. Several recent studies have serendipitously revealed some unexpected things about the organization of chromatin in the nucleus. Genome-wide studies on DNA packaging and on how information is encoded in DNA to influence nucleosome arrangements may be beginning to reveal how enhancers function to regulate genes and how epigenetic modifications can bring about change." @default.
- W2080752929 created "2016-06-24" @default.
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- W2080752929 date "2010-06-01" @default.
- W2080752929 modified "2023-09-26" @default.
- W2080752929 title "Nucleosome positioning, gene regulation and disease" @default.
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- W2080752929 doi "https://doi.org/10.2217/epi.10.23" @default.
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