FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080754682> ?p ?o ?g. }

• W2080754682 endingPage "1505" @default.
• W2080754682 startingPage "1497" @default.
• W2080754682 abstract "<b><i>Background:</i></b> The modes of action of interferon beta (IFN-β) in MS remain unclear, but enhanced levels of the anti-inflammatory cytokine interleukin-10 (IL-10) in the CSF of patients with MS may be a marker of its prognostic efficacy. <b><i>Objective:</i></b> To examine potential mechanisms by which IL-10 may be increased by IFN-β in the milieu of the CNS. <b><i>Methods:</i></b> A model of T cell interaction with microglia in vitro was used. Production of cytokines was monitored by measuring the levels of various cytokine proteins, using ELISA. <b><i>Results:</i></b> Pretreatment of T cells with IFN-β potentiates the production of IL-10 when they interact with adult human microglia, human fetal microglia, or U937 cells treated with phorbol-12-myristate-13-acetate (PMA) and IFN-γ. The enhancing effect of IFN-β on IL-10 requires cell–cell contact, but does not seem to depend on pathways implicated in microglia–T cell interactions, involving CD40, CD23, and B7. In contrast to IL-10, IFN-β inhibits the production of other cytokines, including tumor necrosis factor-α (TNF-α), IL-1β, IL-4, IL-12, and IL-13. <b><i>Conclusions:</i></b> The increase of IL-10 in microglia–T cell interaction by IFN-β together with a decrease of other cytokines may lead to a noninflammatory milieu in the CNS. This mechanism could contribute to the efficacy of IFN-β in MS.–1505" @default.
• W2080754682 created "2016-06-24" @default.
• W2080754682 creator A5029746113 @default.
• W2080754682 creator A5080958470 @default.
• W2080754682 date "2000-11-28" @default.
• W2080754682 modified "2023-10-17" @default.
• W2080754682 title "Interferon beta-1b increases interleukin-10 in a model of T cell-microglia interaction: Relevance to MS" @default.
• W2080754682 cites W1509664796 @default.
• W2080754682 cites W1517658874 @default.
• W2080754682 cites W1589778426 @default.
• W2080754682 cites W1793538934 @default.
• W2080754682 cites W1859478170 @default.
• W2080754682 cites W1898526558 @default.
• W2080754682 cites W1968168664 @default.
• W2080754682 cites W1972193564 @default.
• W2080754682 cites W1975562276 @default.
• W2080754682 cites W1977724594 @default.
• W2080754682 cites W1979358011 @default.
• W2080754682 cites W1981351035 @default.
• W2080754682 cites W1981358487 @default.
• W2080754682 cites W1992239409 @default.
• W2080754682 cites W1996291400 @default.
• W2080754682 cites W1996630186 @default.
• W2080754682 cites W2003460816 @default.
• W2080754682 cites W2013723940 @default.
• W2080754682 cites W2024061399 @default.
• W2080754682 cites W2028746089 @default.
• W2080754682 cites W2031253497 @default.
• W2080754682 cites W2033416083 @default.
• W2080754682 cites W2035013487 @default.
• W2080754682 cites W2036500213 @default.
• W2080754682 cites W2041508820 @default.
• W2080754682 cites W2041951556 @default.
• W2080754682 cites W2047572965 @default.
• W2080754682 cites W2053066468 @default.
• W2080754682 cites W2053136805 @default.
• W2080754682 cites W2060979547 @default.
• W2080754682 cites W2075336031 @default.
• W2080754682 cites W2075838162 @default.
• W2080754682 cites W2083770877 @default.
• W2080754682 cites W2092493402 @default.
• W2080754682 cites W2118744102 @default.
• W2080754682 cites W2126911875 @default.
• W2080754682 cites W2139367012 @default.
• W2080754682 cites W2149071520 @default.
• W2080754682 cites W2154895803 @default.
• W2080754682 cites W2165547142 @default.
• W2080754682 cites W2312313151 @default.
• W2080754682 cites W2412971245 @default.
• W2080754682 doi "https://doi.org/10.1212/wnl.55.10.1497" @default.
• W2080754682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11094104" @default.
• W2080754682 hasPublicationYear "2000" @default.
• W2080754682 type Work @default.
• W2080754682 sameAs 2080754682 @default.
• W2080754682 citedByCount "42" @default.
• W2080754682 countsByYear W20807546822012 @default.
• W2080754682 countsByYear W20807546822013 @default.
• W2080754682 countsByYear W20807546822015 @default.
• W2080754682 countsByYear W20807546822018 @default.
• W2080754682 countsByYear W20807546822019 @default.
• W2080754682 countsByYear W20807546822021 @default.
• W2080754682 countsByYear W20807546822023 @default.
• W2080754682 crossrefType "journal-article" @default.
• W2080754682 hasAuthorship W2080754682A5029746113 @default.
• W2080754682 hasAuthorship W2080754682A5080958470 @default.
• W2080754682 hasConcept C17991360 @default.
• W2080754682 hasConcept C185592680 @default.
• W2080754682 hasConcept C187316574 @default.
• W2080754682 hasConcept C191732599 @default.
• W2080754682 hasConcept C203014093 @default.
• W2080754682 hasConcept C2776178377 @default.
• W2080754682 hasConcept C2776914184 @default.
• W2080754682 hasConcept C2778690821 @default.
• W2080754682 hasConcept C2779830541 @default.
• W2080754682 hasConcept C71924100 @default.
• W2080754682 hasConcept C74172505 @default.
• W2080754682 hasConcept C86803240 @default.
• W2080754682 hasConceptScore W2080754682C17991360 @default.
• W2080754682 hasConceptScore W2080754682C185592680 @default.
• W2080754682 hasConceptScore W2080754682C187316574 @default.
• W2080754682 hasConceptScore W2080754682C191732599 @default.
• W2080754682 hasConceptScore W2080754682C203014093 @default.
• W2080754682 hasConceptScore W2080754682C2776178377 @default.
• W2080754682 hasConceptScore W2080754682C2776914184 @default.
• W2080754682 hasConceptScore W2080754682C2778690821 @default.
• W2080754682 hasConceptScore W2080754682C2779830541 @default.
• W2080754682 hasConceptScore W2080754682C71924100 @default.
• W2080754682 hasConceptScore W2080754682C74172505 @default.
• W2080754682 hasConceptScore W2080754682C86803240 @default.
• W2080754682 hasIssue "10" @default.
• W2080754682 hasLocation W20807546821 @default.
• W2080754682 hasLocation W20807546822 @default.
• W2080754682 hasOpenAccess W2080754682 @default.
• W2080754682 hasPrimaryLocation W20807546821 @default.
• W2080754682 hasRelatedWork W1493607500 @default.
• W2080754682 hasRelatedWork W1567991807 @default.
• W2080754682 hasRelatedWork W1991928333 @default.
• W2080754682 hasRelatedWork W2029380307 @default.

• next