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- W2080758650 abstract "Abnormal proliferations of the endometrium form a morphological continuum ranging from simple glandular hyperplasia to frankly invasive cancer. The extremes of this spectrum of pathology are relatively easily identified and treated. It is the intermediate, varying degrees of closely packed complex glands with cytological atypia that present the most difficulty with regard to diagnosis, and subsequent management. The issue is further compounded by the fact that on the one hand cases of hyperplasia may demonstrate significant cytological atypia, and on the other hand some cases of carcinoma may lack atypia. Various terms have been used to describe lesions in this grey area (e.g. adenomatous hyperplasia, atypical hyperplasia), however, criteria for their diagnosis have been loosely applied by different authors and this is further compounded by the subjective interpretation of histology. The clinical management of women with endometrial hyperplasia is largely dependent on an accurate pathological classification. Given the aforementioned difficulty in making a firm pathological classification in a significant proportion of cases, and the uncertainty of the prognostic implications of the different entities, clinicians are consequently left making important clinical decisions based on poorly defined criteria. The aim of this paper is to clarify the pathological classification of endometrial hyperplasia, to correlate this with prognostic variables and thus, to propose a rational framework for the management of this common condition." @default.
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- W2080758650 date "1997-03-01" @default.
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- W2080758650 title "Diagnosis and management of endometrial hyperplasia" @default.
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- W2080758650 doi "https://doi.org/10.1016/s0957-5847(97)80004-2" @default.
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