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- W2080759256 abstract "Abstract In the cricket Gryllus bimaculatus , missing distal parts of amputated legs are regenerated from blastemas based on positional information. The Dachsous/Fat (Ds/Ft) signaling pathway regulates blastema cell proliferation and positional information along the longitudinal axis during leg regeneration. Herein, we show that the Gryllus homologue of Lowfat ( Gb 'Lft), which modulates Ds/Ft signaling in Drosophila , is involved in leg regeneration. Gb'lft is expressed in regenerating legs, and RNAi against Gb'lft ( Gb'lft RNAi ) suppressed blastema cell hyperproliferation caused by Gb'ft RNAi or Gb'ds RNAi but enhanced that caused by Gb'kibra RNAi or Gb'warts RNAi . In Gb'lft RNAi nymphs, missing parts of amputated legs were regenerated, but the length of the regenerated legs was shortened depending on the position of the amputation. Both normal and reversed intercalary regeneration occurred in Gb'lft RNAi nymphs, suggesting that Gb 'Lft is involved in blastema cell proliferation and longitudinal leg regeneration under the Ds/Ft signaling pathway, but it is not required for intercalary regeneration. Developmental Dynamics 240:1440–1453, 2011. © 2011 Wiley‐Liss, Inc." @default.
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- W2080759256 date "2011-04-28" @default.
- W2080759256 modified "2023-10-18" @default.
- W2080759256 title "Lowfat, a mammalian Lix1 homologue, regulates leg size and growth under the Dachsous/Fat signaling pathway during tissue regeneration†" @default.
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- W2080759256 doi "https://doi.org/10.1002/dvdy.22647" @default.
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