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- W2080763497 endingPage "e57080" @default.
- W2080763497 startingPage "e57080" @default.
- W2080763497 abstract "SNAP-25 is a core component of the trimeric SNARE complex mediating vesicle exocytosis during membrane addition for neuronal growth, neuropeptide/growth factor secretion, and neurotransmitter release during synaptic transmission. Here, we report a novel microRNA mechanism of SNAP-25 regulation controlling motor neuron development, neurosecretion, synaptic activity, and movement in zebrafish. Loss of miR-153 causes overexpression of SNAP-25 and consequent hyperactive movement in early zebrafish embryos. Conversely, overexpression of miR-153 causes SNAP-25 down regulation resulting in near complete paralysis, mimicking the effects of treatment with Botulinum neurotoxin. miR-153-dependent changes in synaptic activity at the neuromuscular junction are consistent with the observed movement defects. Underlying the movement defects, perturbation of miR-153 function causes dramatic developmental changes in motor neuron patterning and branching. Together, our results indicate that precise control of SNAP-25 expression by miR-153 is critically important for proper neuronal patterning as well as neurotransmission." @default.
- W2080763497 created "2016-06-24" @default.
- W2080763497 creator A5003214476 @default.
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- W2080763497 date "2013-02-25" @default.
- W2080763497 modified "2023-10-17" @default.
- W2080763497 title "miR-153 Regulates SNAP-25, Synaptic Transmission, and Neuronal Development" @default.
- W2080763497 cites W1604563087 @default.
- W2080763497 cites W1607993356 @default.
- W2080763497 cites W1618714882 @default.
- W2080763497 cites W1618912177 @default.
- W2080763497 cites W1800024412 @default.
- W2080763497 cites W1917415069 @default.
- W2080763497 cites W1963786196 @default.
- W2080763497 cites W1964189494 @default.
- W2080763497 cites W1967517418 @default.
- W2080763497 cites W1968298152 @default.
- W2080763497 cites W1969822495 @default.
- W2080763497 cites W1975704366 @default.
- W2080763497 cites W1979565277 @default.
- W2080763497 cites W1981186391 @default.
- W2080763497 cites W1983319708 @default.
- W2080763497 cites W1986820918 @default.
- W2080763497 cites W1987615735 @default.
- W2080763497 cites W1989276229 @default.
- W2080763497 cites W1989288106 @default.
- W2080763497 cites W1991660337 @default.
- W2080763497 cites W1993811142 @default.
- W2080763497 cites W1997750064 @default.
- W2080763497 cites W2000302106 @default.
- W2080763497 cites W2001774804 @default.
- W2080763497 cites W2007982098 @default.
- W2080763497 cites W2009510402 @default.
- W2080763497 cites W2009611251 @default.
- W2080763497 cites W2010206624 @default.
- W2080763497 cites W2011940688 @default.
- W2080763497 cites W2013395579 @default.
- W2080763497 cites W2019028138 @default.
- W2080763497 cites W2024136850 @default.
- W2080763497 cites W2029138264 @default.
- W2080763497 cites W2036371475 @default.
- W2080763497 cites W2036959083 @default.
- W2080763497 cites W2040648064 @default.
- W2080763497 cites W2041171360 @default.
- W2080763497 cites W2046491231 @default.
- W2080763497 cites W2049232195 @default.
- W2080763497 cites W2049958342 @default.
- W2080763497 cites W2051370920 @default.
- W2080763497 cites W2056003604 @default.
- W2080763497 cites W2059222949 @default.
- W2080763497 cites W2060033529 @default.
- W2080763497 cites W2061858749 @default.
- W2080763497 cites W2063565555 @default.
- W2080763497 cites W2066513668 @default.
- W2080763497 cites W2069243189 @default.
- W2080763497 cites W2071474610 @default.
- W2080763497 cites W2071483088 @default.
- W2080763497 cites W2072108954 @default.
- W2080763497 cites W2079407969 @default.
- W2080763497 cites W2083922554 @default.
- W2080763497 cites W2084758662 @default.
- W2080763497 cites W2086168599 @default.
- W2080763497 cites W2087938584 @default.
- W2080763497 cites W2088240537 @default.
- W2080763497 cites W2090183355 @default.
- W2080763497 cites W2091811407 @default.
- W2080763497 cites W2096304780 @default.
- W2080763497 cites W2096721619 @default.
- W2080763497 cites W2098863053 @default.
- W2080763497 cites W2104919785 @default.
- W2080763497 cites W2104920243 @default.
- W2080763497 cites W2105037435 @default.
- W2080763497 cites W2116017334 @default.
- W2080763497 cites W2118749647 @default.
- W2080763497 cites W2122977798 @default.
- W2080763497 cites W2125178516 @default.
- W2080763497 cites W2128749538 @default.
- W2080763497 cites W2137163623 @default.
- W2080763497 cites W2137483641 @default.
- W2080763497 cites W2138473891 @default.
- W2080763497 cites W2150737966 @default.
- W2080763497 cites W2153882592 @default.
- W2080763497 cites W2154472809 @default.
- W2080763497 cites W2162983737 @default.
- W2080763497 cites W2165298439 @default.
- W2080763497 cites W2167536144 @default.
- W2080763497 cites W2781692874 @default.
- W2080763497 cites W4211197456 @default.
- W2080763497 cites W4297680000 @default.
- W2080763497 doi "https://doi.org/10.1371/journal.pone.0057080" @default.
- W2080763497 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3581580" @default.