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• W2080763985 abstract "Subsets of murine CD4+ T cells localize to different areas of the spleen after adoptive transfer. Naïve and T helper 1 (TH1) cells, which express the chemokine receptor CCR7, are home to the periarteriolar lymphoid sheath, whereas activated TH2 cells, which lack CCR7, form rings at the periphery of the T cell zones near B cell follicles. Retroviral transduction of TH2 cells with CCR7 forces them to localize in a TH1-like pattern and inhibits their participation in B cell help in vivo but not in vitro. Thus, differential expression of chemokine receptors results in unique cellular migration patterns that are important for effective immune responses." @default.
• W2080763985 created "2016-06-24" @default.
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• W2080763985 date "1999-12-10" @default.
• W2080763985 modified "2023-10-16" @default.
• W2080763985 title "The Role of CCR7 in T_H1 and T_H2 Cell Localization and Delivery of B Cell Help in Vivo" @default.
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• W2080763985 doi "https://doi.org/10.1126/science.286.5447.2159" @default.
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