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• W2080767025 abstract "Hematologic findings and published complete blood cell count criteria were evaluated as screening tests for neonatal sepsis. From the data obtained, a hematologic scoring system was formulated that assigns a score of 1 for each of seven findings: abnormal total leukocyte count, abnormal total neutrophil (PMN) count, elevated immature PMN count, elevated immature to total PMN ratio, Immature to mature PMN ratio ≥0.3, platelet count ≤150,000/mm3, and pronounced degenerative changes in PMNs. There were 298 evaluations for sepsis (243 in the first 24 hours of life and 55 between days 2 and 30). Twenty-six of 27 (96%) infants with sepsis and all 23 infants with probable infection had scores ≥3, compared with 35 of 248 (14%) noninfected infants. The likelihood of sepsis with score ≥3 was 31%, and this value differed with both gestational and postnatal ages (34% vs 8% in preterm and term infants <24 hours of age, and 65% thereafter). The higher the score the greater was the likelihood of sepsis. With score ≤2 the likelihood that sepsis was absent was 99%. The hematologic scoring system should improve the diagnostic accuracy of the complete blood cell count as a screening test for sepsis and could simplify and standardize the interpretation of this global test. Hematologic findings and published complete blood cell count criteria were evaluated as screening tests for neonatal sepsis. From the data obtained, a hematologic scoring system was formulated that assigns a score of 1 for each of seven findings: abnormal total leukocyte count, abnormal total neutrophil (PMN) count, elevated immature PMN count, elevated immature to total PMN ratio, Immature to mature PMN ratio ≥0.3, platelet count ≤150,000/mm3, and pronounced degenerative changes in PMNs. There were 298 evaluations for sepsis (243 in the first 24 hours of life and 55 between days 2 and 30). Twenty-six of 27 (96%) infants with sepsis and all 23 infants with probable infection had scores ≥3, compared with 35 of 248 (14%) noninfected infants. The likelihood of sepsis with score ≥3 was 31%, and this value differed with both gestational and postnatal ages (34% vs 8% in preterm and term infants <24 hours of age, and 65% thereafter). The higher the score the greater was the likelihood of sepsis. With score ≤2 the likelihood that sepsis was absent was 99%. The hematologic scoring system should improve the diagnostic accuracy of the complete blood cell count as a screening test for sepsis and could simplify and standardize the interpretation of this global test." @default.
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• W2080767025 date "1988-05-01" @default.
• W2080767025 modified "2023-10-16" @default.
• W2080767025 title "Early diagnosis of neonatal sepsis using a hematologic scoring system" @default.
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• W2080767025 doi "https://doi.org/10.1016/s0022-3476(88)80699-1" @default.
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