Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080772895> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2080772895 endingPage "487" @default.
- W2080772895 startingPage "484" @default.
- W2080772895 abstract "Methylglyoxal is an α-oxoaldehyde inevitably produced from triose-phosphate intermediates of phosphorylating glycolysis, and also from amino acids and acetone. Recently, the attention has been focused on the involvement of free radicals in methylglyoxal toxicity. In this review, a summary of the relationship between methylglyoxal metabolism and free radical production is presented, extending discussion from the possible metabolic routes to the toxicological events by reviewing the role of free radicals in both generation and degradation of this 1,2-dicarbonyl as well as in the modification of biological macromolecules, and focusing on the action of methylglyoxal upon cellular glutathione content. Methylglyoxal-provoked free radical generation involving reactive oxygen species (ROS), reactive nitrogen species (RNS) as well as organic radicals like methylglyoxal radial or crosslinked protein radical as potential risk factors to tissue damage propagation, is thoroughly discussed. Special attention is paid to the potential therapeutic interventions. The paper arrives at the conclusion that a tight junction exists between methylglyoxal toxicity and free radical (particularly ROS) generation, though the toxicity of 1,2-dicarbonyl evolves even under anaerobic conditions, too. The events follow a sequence beginning with carbonyl stress essential for the toxicity, leading to free radical formation and finally ending in either apoptosis or necrosis. Both oxidative and nitrosative stress play important but not indispensable role in the development of methylglyoxal toxicity." @default.
- W2080772895 created "2016-06-24" @default.
- W2080772895 creator A5010525865 @default.
- W2080772895 creator A5010804848 @default.
- W2080772895 creator A5013819778 @default.
- W2080772895 date "1971-05-01" @default.
- W2080772895 modified "2023-09-27" @default.
- W2080772895 title "Inhibition of in vitro histone acetylation in a cell free rat uterine system by methylglyoxal and phenylglyoxal" @default.
- W2080772895 cites W2018444620 @default.
- W2080772895 cites W2037066522 @default.
- W2080772895 cites W2037343237 @default.
- W2080772895 cites W2047688609 @default.
- W2080772895 cites W2118685775 @default.
- W2080772895 doi "https://doi.org/10.1016/0006-291x(71)90639-5" @default.
- W2080772895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5563315" @default.
- W2080772895 hasPublicationYear "1971" @default.
- W2080772895 type Work @default.
- W2080772895 sameAs 2080772895 @default.
- W2080772895 citedByCount "6" @default.
- W2080772895 crossrefType "journal-article" @default.
- W2080772895 hasAuthorship W2080772895A5010525865 @default.
- W2080772895 hasAuthorship W2080772895A5010804848 @default.
- W2080772895 hasAuthorship W2080772895A5013819778 @default.
- W2080772895 hasConcept C129070979 @default.
- W2080772895 hasConcept C139066938 @default.
- W2080772895 hasConcept C178790620 @default.
- W2080772895 hasConcept C181199279 @default.
- W2080772895 hasConcept C185592680 @default.
- W2080772895 hasConcept C2776151105 @default.
- W2080772895 hasConcept C2778592357 @default.
- W2080772895 hasConcept C29730261 @default.
- W2080772895 hasConcept C48349386 @default.
- W2080772895 hasConcept C538909803 @default.
- W2080772895 hasConcept C55493867 @default.
- W2080772895 hasConceptScore W2080772895C129070979 @default.
- W2080772895 hasConceptScore W2080772895C139066938 @default.
- W2080772895 hasConceptScore W2080772895C178790620 @default.
- W2080772895 hasConceptScore W2080772895C181199279 @default.
- W2080772895 hasConceptScore W2080772895C185592680 @default.
- W2080772895 hasConceptScore W2080772895C2776151105 @default.
- W2080772895 hasConceptScore W2080772895C2778592357 @default.
- W2080772895 hasConceptScore W2080772895C29730261 @default.
- W2080772895 hasConceptScore W2080772895C48349386 @default.
- W2080772895 hasConceptScore W2080772895C538909803 @default.
- W2080772895 hasConceptScore W2080772895C55493867 @default.
- W2080772895 hasIssue "3" @default.
- W2080772895 hasLocation W20807728951 @default.
- W2080772895 hasLocation W20807728952 @default.
- W2080772895 hasOpenAccess W2080772895 @default.
- W2080772895 hasPrimaryLocation W20807728951 @default.
- W2080772895 hasRelatedWork W1995181336 @default.
- W2080772895 hasRelatedWork W2010853298 @default.
- W2080772895 hasRelatedWork W2030362585 @default.
- W2080772895 hasRelatedWork W2037090842 @default.
- W2080772895 hasRelatedWork W2063597580 @default.
- W2080772895 hasRelatedWork W2578996068 @default.
- W2080772895 hasRelatedWork W3087664712 @default.
- W2080772895 hasRelatedWork W4225131613 @default.
- W2080772895 hasRelatedWork W4309099436 @default.
- W2080772895 hasRelatedWork W2188484886 @default.
- W2080772895 hasVolume "43" @default.
- W2080772895 isParatext "false" @default.
- W2080772895 isRetracted "false" @default.
- W2080772895 magId "2080772895" @default.
- W2080772895 workType "article" @default.