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• W2080774472 abstract "This study investigated the efficacy of the plant-based n−3 fatty acid, α-linolenic acid (ALA), a dietary precursor of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), for modulating hepatic steatosis. Rats were fed high fat (55% energy) diets containing high oleic canola oil, canola oil, a canola/flax oil blend (C/F, 3:1), safflower oil, soybean oil, or lard. After 12 weeks, C/F and weight-matched (WM) groups had 20% less liver lipid. Body mass, liver weight, glucose and lipid metabolism, inflammation and molecular markers of fatty acid oxidation, synthesis, desaturation and elongation did not account for this effect. The C/F group had the highest total n−3 and EPA in hepatic phospholipids (PL), as well as one of the highest DHA and lowest arachidonic acid (n−6) concentrations. In conclusion, the C/F diet with the highest content of the plant-based n−3 ALA attenuated hepatic steatosis and altered the hepatic PL fatty acid profile." @default.
• W2080774472 created "2016-06-24" @default.
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• W2080774472 date "2013-11-01" @default.
• W2080774472 modified "2023-09-27" @default.
• W2080774472 title "A diet high in α-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats" @default.
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• W2080774472 doi "https://doi.org/10.1016/j.plefa.2013.09.009" @default.
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