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- W2080777215 abstract "The purpose of this investigation was to develop a sensitive and selective radioimmunoassay for Desglycinamide-Arginine Vasopressin (DGAVP). DGAVP was extracted from rat plasma after protein precipitation, using Sep-Pak C18 cartridges and 50 mM glycine buffer/methanol (10:90) solution. Extraction recovery was 73±14% (mean±S.D.; n=11) and good linearity was achieved in the concentration range of 0.25–128 pg/tube. Instantaneous tracer addition resulted in a detection limit of 250 fg/tube, whereas 24 hours preincubation and delayed tracer addition resulted in a detection limit of 100 fg/tube. Intra-assay variation ranged between 7.4% and 10.0% depending on the peptide concentration and inter-assay variation was 13.2%. Using this procedure, plasma pharmacokinetics of DGAVP in the rat were determined after IV administration. DGAVP plasma concentration showed a rapid distribution phase (t12=1.0±0.2 min) and a somewhat slower elimination phase (t12=7.2±2.1 min). High clearance values (CLss=97±30 ml·min−1) suggest rapid metabolism by amino- and carboxy-peptidases." @default.
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- W2080777215 date "1988-05-01" @default.
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- W2080777215 title "Radioimmunoassay of desglycinamide-arginine vasopressin and its application in a pharmacokinetic study in the rat" @default.
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- W2080777215 doi "https://doi.org/10.1016/0196-9781(88)90163-5" @default.
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